Tuning the structure and performance of silk biomaterials by combining mulberry and non-mulberry silk fibroin
Tuning the structure and performance of silk biomaterials by combining mulberry and non-mulberry silk fibroin
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通过结合桑树和非桑树丝素蛋白来调整丝生物材料的结构和性能
DOI：
10.1016/j.polymdegradstab.2017.11.013
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发表时间：
2018-01-01
影响因子：
5.9
通讯作者：
You, Renchuan
中科院分区：
文献类型：
--
作者：
Li, Xiufang;Zhang, Jie;You, Renchuan
尽管在丝素蛋白（SF）的生物医学应用方面做出了相当大的努力，但对丝生物材料的结构和性能的详细控制仍然是一个重大挑战。桑蚕丝分为桑葚和非桑蚕丝，分别由家蚕和野蚕生产。为了获得性能可调的蚕丝生物材料，将桑蚕丝素蛋白（BSF）和非桑蚕丝素蛋白（ASF）共混。这些系统利用了两种丝蛋白的有益材料和生物学特性。ASF的溶胶-凝胶转变比BSF快得多。因此，SF溶液的凝胶化速率可以通过改变ASF比率控制在几十分钟到几天的范围内，为制备丝水凝胶提供了有用的选择。提高共混材料中的BSF比率显著提高了机械性能，克服了再生ASF材料机械性能的固有不足。相反，增加ASF比率显著增强共混膜的降解性，为丝生物材料的降解速率提供更宽的调节范围。因此，这种简单的共混策略使该过程更加可控和灵活，控制丝蛋白的性能变得可行，这将大大扩展丝作为生物医学材料的应用。
Despite considerable efforts toward the biomedical applications of silk fibroin (SF), detailed control of structure and performance in silk biomaterials remains a major challenge. Silks are classified as mulberry and non-mulberry, which are produced by domesticated Bombyx mori and wild silkworm species, respectively. To achieve silk biomaterials with tunable performance, Bombyx mori silk fibroin (BSF) and non-mulberry Antheraea pernyi silk fibroin (ASF) were blended. These systems exploit the beneficial material and biological properties of both silk proteins. The sol-gel transition of ASF was much more rapid than that of BSF. Consequently, the gelation rate of SF solution could be controlled ranging from tens of minutes to days by changing the ASF ratio, providing useful options for the fabrication of silk hydrogels. Raising BSF ratio in the blend materials significantly increased mechanical performance, overcoming the inherent lack of mechanical performances of regenerated ASF materials. Conversely, increasing ASF ratio significantly enhanced degradability of the blend films, providing a wider range of regulation for the degradation rate of silk biomaterials. As a result, this simple blending strategy enables the process to be more controllable and flexible, controlling the performance of silk protein becomes feasible, and this would greatly expand the applications of silk as a biomedical material.