Chlorhexidine varnish for preventing dental caries in children, adolescents and young adults: a systematic review.
Chlorhexidine varnish for preventing dental caries in children, adolescents and young adults: a systematic review.
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用于预防儿童、青少年和年轻人龋齿的氯己定清漆：系统评价。
DOI：
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发表时间：
2006
影响因子：
1.9
通讯作者：
G. Truin
中科院分区：
文献类型：
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作者：
Qi Zhang;W. H. van Palenstein Helderman;M. V. van’t Hof;G. Truin
本系统综述旨在探讨氯己定（CHX）清漆对儿童、青少年和年轻人恒牙列的龋抑制作用，并探讨使用频率和评价与最后一次使用的时间两个可能的相关因素。文献检索确定了14篇随机对照试验或对照临床试验的出版物，其中CHX清漆的效果与安慰剂对照组或未接受预防治疗的对照组进行了比较。为了获得均匀的结局效果，计算龋齿增加的预防分数和95%置信区间。由于提供的数据不足，只列入了8份出版物。在收到作者提供的额外数据后，又纳入了另外两篇出版物。由于结果的差异很大，因此无法计算总体预防比例，因此该系统评价没有进行荟萃分析。这种变化不能用评估和最后一次应用之间的时间来解释，但可以用应用频率来解释。初步认为CHX清漆每3-4个月涂一次，有中等抑龋效果。然而，这种效果似乎在最后一次应用后2年左右就减弱了。没有证据表明CHX清漆的龋抑制效果与较长的应用间隔。
This systematic review aimed to determine the caries-inhibiting effect of chlorhexidine (CHX) varnishes on the permanent dentition of children, adolescents and young adults, and to explore two possibly related factors, namely application frequency and the time between evaluation and the last application. The literature search identified 14 publications of randomized controlled trials or controlled clinical trials where the effect of CHX varnish was compared with placebo controls or controls that received no preventive treatment. To obtain uniform outcome effects, the prevented fraction and 95% confidence intervals of caries increment were calculated. Owing to insufficient data presentation, only eight publications were included. Another two publications were included after receiving additional data from the authors. This systematic review did not result in a meta-analysis as an overall prevented fraction could not be computed because of the large variation of outcome results. The variation could not be explained by the time between evaluation and last application but might be explained by application frequency. It is tentatively concluded that CHX varnish has a moderate caries-inhibiting effect when applied every 3-4 months. However, this effect seems to have diminished by around 2 yr after the last application. There is no evidence for a caries-inhibiting effect of CHX varnish with longer intervals between applications.