Spindle frequencies in sleep EEG show U-shape within first four NREM sleep episodes
Spindle frequencies in sleep EEG show U-shape within first four NREM sleep episodes
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DOI：
10.1046/j.1365-2869.2002.00273.x
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发表时间：
2002-03-01
影响因子：
4.4
通讯作者：
Hasan, J
中科院分区：
文献类型：
--
作者：
Himanen, SL;Virkkala, J;Hasan, J
睡眠脑电图（EEG）的研究表明，夜间开始时，纺锤波速度较慢，到夜间结束时，纺锤波速度加快。通过光谱分析得到了相应的结果。本研究是基于我们的初步观察，较慢的纺锤波被发现在中间的非快速眼动（NREM）睡眠事件相比，开始或结束的事件。研究了8名健康女性和6名男性受试者。视觉选择睡眠纺锤波，并计算每个NREM睡眠事件中11个分析点的纺锤波频率。在NREM睡眠中，纺锤波频率的中位数形成了一个明显的U形，最初减少，最后增加。在前四次NREM睡眠中，这种下降具有统计学意义。纺锤波频率模式可以用于揭示睡眠阶段2内睡眠深度的变化。在动物研究中，已经发现纺锤体频率与丘脑皮质细胞超极化-反弹序列的持续时间相关。如果假设相同的细胞机制负责人类的纺锤波频率，那么对纺锤波频率变化的研究可以用来检查人类的NREM睡眠过程。
It has been shown in previous studies on sleep electroencephalogram (EEG) that spindles are slower in the beginning of the night fastening towards the end of the night. Corresponding findings have been obtained by spectral analysis. The present study was based on our preliminary observation that slower spindles are found in the middle of the nonrapid eye movement (NREM) sleep episodes as compared with the beginning or the end of the episodes. Eight healthy female and six male subjects were studied. Sleep spindles were visually selected and spindle frequencies calculated for 11 analysis points in each NREM sleep episode. The median spindle frequencies formed a clear U-shape within NREM sleep episodes with an initial decrease and final increase. The decrease was statistically significant within the first four NREM sleep episodes. It is possible that the spindle frequency pattern could be used to reveal variations in sleep depth within sleep stage 2. In animal studies the spindle frequency has been found to be associated to the duration of the hyperpolarization-rebound sequences of the thalamocortical cells. If it is assumed that the same cellular mechanisms are responsible for spindle frequencies in humans then the study of variations in spindle frequency could be used to examine the NREM sleep process in humans.