Viral precursor polyproteins: keys of regulation from replication to maturation.
Viral precursor polyproteins: keys of regulation from replication to maturation.
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DOI：
10.1016/j.coviro.2013.03.009
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发表时间：
2013-04
影响因子：
5.9
通讯作者：
Marcotrigiano, Joseph
中科院分区：
文献类型：
--
作者：
Yost, Samantha A.;Marcotrigiano, Joseph
病毒多聚蛋白以一种在空间和时间上受调控的方式被裂解。对裂解位点的可及性通过各种机制受到高度调控。裂解可导致末端的结构重排。许多病毒采用一种涉及大型多聚蛋白翻译的复制策略，该多聚蛋白由病毒和/或细胞蛋白酶裂解。其中一些病毒对全球人类健康造成严重影响，包括人类免疫缺陷病毒（HIV）、丙型肝炎病毒（HCV）、登革热病毒和西尼罗河病毒。这种基因组组织方式对病毒有许多益处，例如遗传物质的浓缩，以及根据多聚蛋白裂解状态对蛋白质活性进行时间和空间上的调控。对多聚蛋白前体的研究对于充分理解病毒感染以及确定可能的新药物靶点是必要的；然而，目前可用的原子结构很少。这里呈现的是来自具有正链RNA基因组的病毒的四种近期多聚蛋白前体的结构。
Viral polyproteins are cleaved in a spatially and temporally regulated manner. Access to the cleavage site is highly regulated through various mechanisms. Cleavage can result in structural rearrangement of the termini. Many viruses use a replication strategy involving the translation of a large polyprotein, which is cleaved by viral and/or cellular proteases. Several of these viruses severely impact human health around the globe, including HIV, HCV, Dengue virus, and West Nile virus. This method of genome organization has many benefits to the virus such as condensation of genetic material, as well as temporal and spatial regulation of protein activity depending on polyprotein cleavage state. The study of polyprotein precursors is necessary to fully understand viral infection, and identify possible new drug targets; however, few atomic structures are currently available. Presented here are structures of four recent polyprotein precursors from viruses with a positive sense RNA genome.
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