Tuning PEG-DA hydrogel properties via solvent-induced phase separation (SIPS)().
Tuning PEG-DA hydrogel properties via solvent-induced phase separation (SIPS)().
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DOI：
10.1039/c1jm13943f
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发表时间：
2011-01-01
影响因子：
--
通讯作者：
Grunlan MA
中科院分区：
文献类型：
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作者：
Bailey BM;Hui V;Fei R;Grunlan MA
聚乙二醇二丙烯酸酯 (PEG-DA) 水凝胶被广泛用于探测细胞-材料相互作用，并最终用于材料引导的组织再生方法。在这项研究中，通过溶剂诱导相分离（SIPS）制备PEG-DA水凝胶，以获得具有更广泛的可调节物理性质的水凝胶，包括形态（例如孔隙率）、膨胀和模量（G'）。与由水性前体溶液制备的传统 PEG-DA 水凝胶相比，报道的 SIPS 方案使用二氯甲烷 (DCM) 前体溶液，该溶液依次光聚合、干燥和水合。通过改变 PEG-DA wt% 浓度 (5 wt%–25 wt%) 和 Mn (3.4k 和 6k g mol -1) 进一步定制物理特性。 SIPS 生产的 PEG-DA 水凝胶具有大孔形态，并且与相应的传统 PEG-DA 水凝胶相比，G' 值有所增加。值得注意的是，由于与相应的常规 PEG-DA 水凝胶相比，总溶胀没有显着变化，成对或系列的水凝胶代表其中形态和水合或 G' 和水合解偶联的支架。此外，通过 SIPS 制备的 PEG-DA 水凝胶表现出更高的降解率。
Poly(ethylene glycol) diacrylate (PEG-DA) hydrogels are widely utilized to probe cell-material interactions and ultimately for a material-guided approach to tissue regeneration. In this study, PEG-DA hydrogels were fabricated via solvent-induced phase separation (SIPS) to obtain hydrogels with a broader range of tunable physical properties including morphology (e.g. porosity), swelling and modulus (G′). In contrast to conventional PEG-DA hydrogels prepared from an aqueous precursor solution, the reported SIPS protocol utilized a dichloromethane (DCM) precursor solution which was sequentially photopolymerized, dried and hydrated. Physical properties were further tailored by varying the PEG-DA wt% concentration (5 wt%–25 wt%) and Mn (3.4k and 6k g mol −1). SIPS produced PEG-DA hydrogels with a macroporous morphology as well as increased G′ values versus the corresponding conventional PEG-DA hydrogels. Notably, since the total swelling was not significantly changed versus the corresponding conventional PEG-DA hydrogels, pairs or series of hydrogels represent scaffolds in which morphology and hydration or G′ and hydration are uncoupled. In addition, PEG-DA hydrogels prepared via SIPS exhibited enhanced degradation rates.