Development of a hypoxic nanocomposite containing high-Z element as 5-fluorouracil carrier activated self-amplified chemoradiotherapy co-enhancement
Development of a hypoxic nanocomposite containing high-Z element as 5-fluorouracil carrier activated self-amplified chemoradiotherapy co-enhancement
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开发含有高 Z 元素的缺氧纳米复合材料作为 5-氟尿嘧啶载体激活自放大放化疗协同增强
DOI：
10.1098/rsos.181790
复制
发表时间：
2019-06
影响因子：
3.5
通讯作者：
Hong Quan
中科院分区：
文献类型：
--
作者：
Cui Yang;Shan Peng;Yingming Sun;Hongtao Miao;Meng Lyu;Shijing Ma;Yuan Luo;Rui Xiong;Conghua Xie;Hong Quan
化疗和放射治疗成果的协同效应令人鼓舞，但由于普遍存在低氧，导致实体肿瘤对药物/辐射产生抗药性，这一作用受到了严重制约。为了解决这一问题，提高癌症治疗的效率，本研究成功地设计并合成了甲硝唑(MI)、5-氟尿嘧啶(5-FU)和亚铁铂磁性纳米颗粒(MNPs)共输送的片状多功能氧化石墨烯(GO)给药系统，其平均粒径为243 nm。低氧药物载体同时负载放射增敏剂和化疗药物，在单个纳米平台内结合了低氧敏感性和放化疗协同增强的特性，有望为肿瘤的治疗提供新的思路。通过体外实验，证明了纳米复合材料的细胞内活性氧自由基(ROS)对低氧的敏感性和细胞毒性。此外，还揭示了MI、5-FU和FePT MNPs在细胞毒性和辐射增敏方面的相加效应。它增强了对细胞增殖的抑制，并组成了一个自我放大的放射治疗增强系统，同时提高了辐射效率和细胞的辐射敏感性。总之，这项研究推荐了一种新颖而有前景的多功能纳米平台，它具有自我放大效应，可以激活放化疗联合增强。
The synergetic effect of chemoradiotherapy achievement is encouraging but significantly hampered by the prevalence of hypoxia, leading to drug/radiation resistance in solid tumours. To address the problem and improve the efficiency of cancer therapy, a lamellar-structure multifunctional graphene oxide (GO) drug-delivery system with an average size of 243 nm, co-delivering of metronidazole (MI), 5-fluorouracil (5-FU) and FePt magnetic nanoparticles (MNPs), was successfully designed and synthesized in the study. The integration of hypoxic drug carrier loading radiosensitizers and chemotherapeutic drugs simultaneously, combines the properties of hypoxia-sensitivity and chemoradiotherapy co-enhancement within a single nanoplatform, which is expected to provide new ideas for cancer treatment. Through in vitro tests, the hypoxia-sensitivity and cytotoxicity of intracellular reactive oxygen species (ROS) of the nanocomposites (NCs) were proved. Moreover, the additive effect between MI, 5-FU and FePt MNPs in cytotoxicity and radiation sensitization aspects is disclosed. It performs an enhanced cell proliferation inhibition and makes up a self-amplified radiotherapy enhancement system that improves radiation efficiency and cell radiosensitivity simultaneously. In conclusion, the study recommended a novel and promising multifunctional nanoplatform which performed a self-amplified effect that activated chemoradiotherapy co-enhancement.
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DOI：
10.3390/molecules13081551
发表时间：
2008-08-05
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Zhang N;Yin Y;Xu SJ;Chen WS
通讯作者：
Chen WS
DOI：
10.3390/molecules13071441
发表时间：
2008-06-28
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Tsume Y;Vig BS;Sun J;Landowski CP;Hilfinger JM;Ramachandran C;Amidon GL
通讯作者：
Amidon GL
影响因子：
38.3
作者：
Min Y;Roche KC;Tian S;Eblan MJ;McKinnon KP;Caster JM;Chai S;Herring LE;Zhang L;Zhang T;DeSimone JM;Tepper JE;Vincent BG;Serody JS;Wang AZ
通讯作者：
Wang AZ
FEPT纳米颗粒作为HeLa细胞的潜在X射线激活化学疗法。
影响因子：
8
作者：
Zheng Y;Tang Y;Bao Z;Wang H;Ren F;Guo M;Quan H;Jiang C
通讯作者：
Jiang C
影响因子：
3.5
作者：
Hao Y;Altundal Y;Moreau M;Sajo E;Kumar R;Ngwa W
通讯作者：
Ngwa W