POSTINGESTIONAL EFFECTS OF A HIGH-PROTEIN DIET ON THE REGULATION OF FOOD-INTAKE IN MONKEYS
POSTINGESTIONAL EFFECTS OF A HIGH-PROTEIN DIET ON THE REGULATION OF FOOD-INTAKE IN MONKEYS
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DOI：
10.1093/ajcn/52.2.320
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发表时间：
1990-08-01
影响因子：
7.1
通讯作者：
HANSEN, BC
中科院分区：
文献类型：
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作者：
HANNAH, JS;DUBEY, AK;HANSEN, BC
我们使用了一个系统，在这个系统中，胃内饮食的组成可以被控制，而口服因素保持不变，我们研究了高蛋白饮食对食物摄入的影响。四只被长期植入胃内插管的成年恒河猴被训练使用由计算机监控的吸吮激活的食物泵，这样可以在平均每只4周的时间内评估进食模式。每次吸吮的同时，会激活第二个泵，将第二种饮食直接送入胃中，从而使净饮食成分含有14%或50%的蛋白质。卡路里摄入量持续减少24.7% +-。当饲喂高蛋白饮食时，对摄入量的影响不是由于饮食渗透压的增加。饲喂高蛋白饲料时，血浆支链氨基酸浓度增加一倍。这些数据表明，饲喂高蛋白饲料会导致生理食欲抑制，可能是通过支链氨基酸介导的。
Using a system in which the composition of an intragastric diet could be manipulated while oral factors were kept constant, we studied the effect of a high-protein diet on food intake. Four adult rhesus monkeys with chronically implanted intragastric cannulas were trained to use suction-activated food pumps that were monitored by computer so feeding pattern could be assessed over periods averaging 4 wk each. Each suck delivered the oral control diet while simultaneously activating a second pump, which delivered a second diet directly into the stomach, resulting in net diet compositions of either 14% or 50% protein. The calorie intake was consistently reduced by 24.7 .+-. 1.6% when the high-protein diet was fed. The effect on intake was not due to increased diet osmolality. A doubling in plasma branched-chain amino acid concentration occurred when the high-protein diet was fed. These data indicate that feeding a high-protein diet results in a physiological appetite suppression, possibly mediated through branched-chain amino acids.