Pretreatment and longitudinal studies of neuropsychological deficits in antipsychotic-naive patients with schizophrenia
Pretreatment and longitudinal studies of neuropsychological deficits in antipsychotic-naive patients with schizophrenia
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DOI：
10.1016/s0920-9964(03)00213-5
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发表时间：
2004-05-01
影响因子：
4.5
通讯作者：
Sweeney, JA
中科院分区：
文献类型：
--
作者：
Hill, SK;Schuepbach, D;Sweeney, JA
需要更好地明确精神分裂症神经心理功能障碍的早期病程以及治疗对这些缺陷的影响。 45 名精神分裂症患者在接受抗精神病药物治疗前至 2 年随访期间接受了 5 次神经心理学评估。 33 名匹配的健康个体的比较样本在相似的时间点接受了神经心理学评估。在基线时，精神分裂症样本的跨认知领域普遍存在缺陷。治疗 6 周后，患者的视觉记忆和视觉感知略有改善，但言语记忆有所下降。在 6 个月的随访中，言语记忆表现恢复到基线水平，而其他神经心理学领域的缺陷在整个 2 年期间持续存在。从疾病发作就可以明显看出，相对静态和普遍的神经心理功能障碍与精神分裂症的神经发育模型而不是神经退行性模型一致。 (C) 2003 Elsevier B.V. 保留所有权利。
The early course of neuropsychological dysfunction in schizophrenia and the impact of treatment on these deficits need to be better specified. A sample of 45 patients with schizophrenia underwent five neuropsychological evaluations from prior to treatment with antipsychotic treatment through a 2-year follow-up period. A comparison sample of 33 matched healthy individuals underwent neuropsycliological evaluations at similar time points. At baseline, a generalized deficit across cognitive domains was evident for the schizophrenia sample. After 6 weeks of treatment, patients showed modest improvements in visual memory and visual perception, but a decline in verbal memory. Verbal memory performance returned to baseline levels by the 6-month follow-up while deficits in other neuropsychological domains persisted throughout the 2-year period. Relatively static and generalized neuropsychological dysfunction, evident from illness onset, is consistent with neurodevelopmental rather than neurodegenerative models of schizophrenia. (C) 2003 Elsevier B.V. All rights reserved.