Hormonal contraception and HIV acquisition: reanalysis using marginal structural modeling.
Hormonal contraception and HIV acquisition: reanalysis using marginal structural modeling.
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DOI：
10.1097/qad.0b013e32833a2537
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发表时间：
2010-07-17
期刊：
影响因子：
--
通讯作者：
Salata RA
中科院分区：
文献类型：
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作者：
Morrison CS;Chen PL;Kwok C;Richardson BA;Chipato T;Mugerwa R;Byamugisha J;Padian N;Celentano DD;Salata RA
激素避孕药在全世界广泛使用;它们对艾滋病毒感染的影响仍未得到解决。我们使用边际结构模型重新分析了激素避孕和HIV研究的数据，以减少由于时间依赖性混杂引起的选择偏倚。密切复制我们最初的分析，我们发现醋酸甲羟孕酮（DMPA）而不是复方口服避孕药（COC）与艾滋病毒感染增加有关。此外，使用DMPA和COCs的年轻（18-24岁）而非老年妇女的艾滋病毒风险增加。
Hormonal contraceptives are used widely worldwide; their effect on HIV acquisition remains unresolved. We reanalyzed data from the Hormonal Contraception and HIV Study using marginal structural modeling to reduce selection bias due to time-dependent confounding. Replicating our original analysis closely, we found that depo-medroxyprogesterone acetate (DMPA) but not combined oral contraceptive (COC) was associated with increased HIV acquisition. Also, young (18–24 years) but not older women who used DMPA and COCs were at increased HIV risk.