Association of race and other potential risk factors with nonvertebral fractures in community-dwelling elderly women.
Association of race and other potential risk factors with nonvertebral fractures in community-dwelling elderly women.
复制标题
种族和其他潜在危险因素与社区老年妇女非椎骨骨折的关联。
DOI：
10.1093/oxfordjournals.aje.a009744
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发表时间：
1999
影响因子：
5
通讯作者：
Gold,DT
中科院分区：
文献类型：
--
作者：
Bohannon,AD;Hanlon,JT;Landerman,R;Gold,DT
这项研究确定了影响骨代谢的社会人口学、生活方式、健康和药物使用因素与发生的非脊椎骨折之间的潜在联系。基线样本由2590名女性非代理受试者组成，这些受试者来自杜克大学老年流行病学研究的既定人群，该研究重点关注北卡罗来纳州皮埃蒙特地区的五个相邻县。有关潜在危险因素的信息是在1986-1987年间的一次基线家庭访谈中收集的。随后的非椎体骨折在年度随访期(1988-1993)的随访中被报道。作者使用了多变量分析，其中加权数据被调整用于抽样设计。在控制了其他潜在的混杂社会人口、生活方式、健康和吸毒因素后，他们发现非裔美国人种族(调整后的优势比(OR)=0.43，95%可信区间(CI)0.31-0.58)、年龄(调整后的OR=1.04，95%可信区间1.01-1.06)、饮酒(调整后的OR=1.61，95%的CI 1.01-2.57)、体重不足(调整后的OR=1.63，95%的CI 1.13-2.34)、认知障碍(调整后的OR=1.67，(95%CI 1.12~2.48)、活动能力受损(调整后OR=1.15，95%CI 1.03~1.29)和苯妥英钠使用(调整后OR%2.93，95%CI 1.04~8.30)与首次骨折发生有关。在非髋部、非脊椎骨折中也观察到了类似的结果。非裔美国人比白人更不可能患有非脊椎骨折，而且这些差异与本研究中检查的生活方式或健康因素无关。
This study determined potential associations of sociodemographic, lifestyle, health, and drug use factors known to affect bone metabolism with incident nonvertebral fractures. The baseline sample consisted of 2,590 female, nonproxy subjects from the Duke Established Populations for Epidemiologic Studies of the Elderly, which focuses on five adjacent counties in the Piedmont area of North Carolina. Information about potential risk factors was collected during a baseline in-home interview during 1986-1987. Subsequent nonvertebral fractures were reported at follow-up interviews during the annual follow-up periods (1988-1993). The authors used multivariate analyses in which weighted data were adjusted for sampling design. After controlling for other potential confounding sociodemographic, lifestyle, health, and drug use factors, they found that African American race (adjusted odds ratio (OR) = 0.43, 95% confidence interval (Cl) 0.31-0.58), age (adjusted OR = 1.04, 95% Cl 1.01-1.06), alcohol consumption (adjusted OR = 1.61, 95% Cl 1.01-2.57), being underweight (adjusted OR = 1.63, 95% Cl 1.13-2.34), cognitive impairment (adjusted OR = 1.67, 95% Cl 1.12-2.48), impaired mobility (adjusted OR = 1.15, 95% Cl 1.03-1.29), and phenytoin use (adjusted OR % 2.93, 95% Cl 1.04-8.30) were associated with first fracture occurrence. Similar findings were observed for nonhip, nonvertebral fractures. African Americans were less likely than Whites to have nonvertebral fractures, and these differences were not related to lifestyle or health factors examined in this study.Am J Epidemiol1999; 149:1002–9.