Magnetic solid-phase extraction of non-steroidal anti-inflammatory drugs from environmental water samples using polyamidoamine dendrimer functionalized with magnetite nanoparticles as a sorbent
Magnetic solid-phase extraction of non-steroidal anti-inflammatory drugs from environmental water samples using polyamidoamine dendrimer functionalized with magnetite nanoparticles as a sorbent
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DOI：
10.1016/j.talanta.2018.02.069
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发表时间：
2018-06-01
期刊：
影响因子：
6.1
通讯作者：
Maleki, Behrooz
中科院分区：
文献类型：
--
作者：
Alinezha, Heshmatollah;Amiri, Amirhassan;Maleki, Behrooz
制备了一种以Fe3O4纳米粒子（Fe3O4@PAMAM）为官能团的新型聚胺胺树状大分子，并将其用作磁性固相萃取（MSPE）吸附剂。采用x射线粉末衍射、傅里叶变换红外光谱、场发射扫描电子能谱、元素分析和热重分析对Fe3O4@PAMAM纳米复合材料进行了表征。采用MSPE -高效液相色谱-紫外检测系统对非甾体类抗炎药（NSAIDs）进行分离分析。对影响所选药物提取效率的主要参数进行了优化。在最佳条件下，该方法的富集系数为701 ~ 835。线性范围为0.15 ~ 500 ng mL(-1)，检出限为0.05 ~ 0.08 ng mL(-1)，相关系数(r)为0.9932 ~ 0.9967，相对标准偏差（RSD）为4.5 ~ 7.0% （n = 5、0.2、10、300 ng mL(-1)）。该方法可用于实际水样中非甾体抗炎药的测定。加标水样的加标回收率为93.6 ~ 98.9%，rsd为6.1% ~ 9.0%，准确度较高。
A novel polyamidoamine dendrimer functionalized with Fe3O4 nanoparticles (Fe3O4@PAMAM) had been fabricated and used as magnetic solid-phase extraction (MSPE) adsorbent. The Fe3O4@PAMAM nanocomposites were characterized by X-ray powder diffraction, Fourier transform infrared spectroscopy, field-emission scanning electron spectroscopy, elemental analytical, and thermal gravimetric analysis. The MSPE method coupled with high-performance liquid chromatography with an ultraviolet detection system was applied for the separation/analysis of non-steroidal anti-inflammatory drugs (NSAIDs). Major parameters affecting the extraction efficiency of the selected drugs were optimized. Under optimal conditions, the enrichment factors for the proposed method were 701-835. The linear range, limit of detection, correlation coefficient (r), and relative standard deviation (RSD) were found to be 0.15-500 ng mL(-1), 0.05-0.08 ng mL(-1), 0.9932-0.9967, and 4.5-7.0% (n = 5, 0.2, 10 and 300 ng mL(-1)) respectively. The method was successfully applied to the determination of NSAIDs in the real water samples. The recoveries of spiked water samples were in the range of 93.6-98.9% with RSDs varying from 6.1% to 9.0%, showing the good accuracy of the method.