Catalytic enantioselective Strecker reaction of ketoimines using catalytic amount of TMSCN and stoichiometric amount of HCN
Catalytic enantioselective Strecker reaction of ketoimines using catalytic amount of TMSCN and stoichiometric amount of HCN
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DOI：
10.1016/j.tetlet.2004.02.077
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发表时间：
2004-04-05
影响因子：
1.8
通讯作者：
Shibasaki, M
中科院分区：
文献类型：
--
作者：
Kato, N;Suzuki, M;Shibasaki, M
在酮亚胺的对映选择性Strecker反应中实现了低至0.1mol%的催化剂负载。以催化量的TMSCN和化学计量量的HCN为试剂，以手性钆配合物为催化剂，得到了良好的对映选择性。(C)2004爱思唯尔有限公司保留所有权利。
Catalyst loading as low as 0.1 mol% was achieved in the enantioselective Strecker reaction of ketoimines. Excellent enantioselectivity was obtained with a combined use of a catalytic amount of TMSCN and a stoichiometric amount of HCN as a reagent, and a chiral gadolinium complex as a catalyst. (C) 2004 Elsevier Ltd. All rights reserved.