Six novel gammaherpesviruses of Afrotheria provide insight into the early divergence of the Gammaherpesvirinae
Six novel gammaherpesviruses of Afrotheria provide insight into the early divergence of the Gammaherpesvirinae
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DOI：
10.1016/j.vetmic.2007.08.024
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发表时间：
2008-03-18
影响因子：
3.3
通讯作者：
Isaza, Ramiro
中科院分区：
文献类型：
--
作者：
Wellehan, James F. X.;Johnson, April J.;Isaza, Ramiro
无肢动物是胎盘哺乳动物的早期分支。以前仅鉴定出两种来自非洲壶属的疱疹病毒，并且已提出它们属于乙型疱疹病毒亚科的鼻病毒属。通过DNA聚合酶基因的检测和分析，在4种超目非洲壶目动物中鉴定出6种新型伽玛疱疹病毒。从亚洲象结膜拭子中鉴定出大象疱疹病毒3型（ElHV3）和大象疱疹病毒4型（ElHV4）。在一头患有阴道炎的大象的阴道拭子中也发现了ElHV3病毒。从两只阴道有斑块的亚洲象阴道拭子中鉴定出5型象疱疹病毒（ElHV5）。在一头非洲象（Loxodonta africana）的结膜拭子中发现了6型象疱疹病毒。在岩兔（Procavia capensis）的脾脏和结膜拭子中检出原原性疱疹病毒1型（PrHV1）。从佛罗里达海牛（trichecchus manatus latirostris）的皮肤和褐色皮毛中鉴定出1型滴虫疱疹病毒（TrHV1）。ElHV3和ElHV4形成一个独立的集群，ElHV5、ElHV6、TrHV1和PrHV1形成第二个集群。这些病毒可能与其宿主物种共分化。对这些新型疱疹病毒的系统发育分析表明，两组不同的伽玛疱疹病毒可能与非洲动物共分化。(C) 2007 Elsevier B.V.版权所有
The Afrotheria represent an early branching of placental mammals. Only two herpesviruses from Afrotheria have been previously identified, and the genus Proboscivirus in the subfamily Betaherpesvirinae has been proposed for them. Six novel gammaherpesviruses were identified in four species in the superorder Afrotheria by detection and analysis of their DNA polymerase genes. Elephantid herpesvirus 3 (ElHV3) and Elephantid herpesvirus 4 (ElHV4) were identified from conjunctival swabs from Asian elephants (Elephas maximus). ElHV3 was also found in a vaginal swab from one elephant with vaginitis. Elephantid herpesvirus 5 (ElHV5) was identified from vaginal swabs of two Asian elephants with vaginal plaques. Elephantid herpesvirus 6 was discovered in a conjunctival swab from an African elephant (Loxodonta africana). Procavid herpesvirus 1 (PrHV1) was found in spleen and conjunctival swabs of rock hyrax (Procavia capensis). Trichechid herpesvirus 1 (TrHV1) was identified from skin and buffy coats of Florida manatees (Trichechus manatus latirostris). ElHV3 and ElHV4 form a distinct cluster, and ElHV5, ElHV6, TrHV1, and PrHV1 form a second cluster. These viruses may have codiverged with their host species. Phylogenetic analysis of these novel herpesviruses suggests that two separate groups of gammaherpesviruses may have codiverged with the Afrotheria. (C) 2007 Elsevier B.V. All rights reserved.