The Mechanism of Canine Atrial Flutter
The Mechanism of Canine Atrial Flutter
复制标题
犬心房扑动的机制
DOI：
10.1161/01.res.20.5.496
复制
发表时间：
1967
影响因子：
20.1
通讯作者：
D. A. Rytand
中科院分区：
文献类型：
--
作者：
W. Hayden;E. Hurley;D. A. Rytand
在麻醉狗中，从六个心房心外膜部位和肢体或食管导联同时记录电描记图，以研究腔间挤压后电诱发心房扑动的机制，并与乌头碱诱发的心房心动过速进行比较。在前者中，肢体导联记录在形式和规律性上类似于经典的人类扑动，激活占据了心房周期的大部分，并按顺序在右心房尾部和左心房前部进行（逆时针扑动）；扑动通常由从最初的挤压延伸到右房室交界处的另一次挤压而终止。肢体和食管导联中最突出的波与左心房活动一致。有时激活是顺时针进行的。在逆时针扑动期间，两个心耳可能同时被激活。这些发现支持马戏团运动假说作为纯心房扑动的机制。相比之下，对于乌头碱速缩，两个心房的激活同时进行，而且时间非常短，以至于使大部分稍微不规则的心房周期处于电静默状态。尽管乌头碱后的肢体导联有时与扑动相似，但兴奋方向和持续时间的对比表明两种心律失常之间存在深刻的生理差异。
In anesthetized dogs, electrograms were recorded simultaneously from six atrial epicardial sites and a limb or esophageal lead in order to study the mechanism of atrial flutter induced electrically after an intercaval crush in comparison with atrial tachysystole induced by aconitine. In the former, with limb lead records resembling classical human flutter in form and regularity, activation occupied most of the atrial cycle and progressed in sequence caudally in the right atrium and cranially in the left (counterclockwise flutter); flutter was usually terminated by another crush extending from the initial one to the right atrioventricular junction. The most prominent wave in limb and esophageal leads coincided with left atrial activity. Sometimes activation proceeded clockwise. The two atrial appendages may be activated simultaneously during counterclockwise flutter. These findings support the circus movement hypothesis as the mechanism of pure atrial flutter. In contrast, with aconitine tachysystole, activation proceeded over both atria at once and was so brief that it left most of the slightly irregular atrial cycle electrically silent. Although limb leads after aconitine sometimes resembled those of flutter, the contrast in direction and duration of excitation demonstrates profound physiological differences between the two arrhythmias.