Developing a reference system for the IFCC standardization of HbA2
Developing a reference system for the IFCC standardization of HbA2
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DOI：
10.1016/j.cca.2016.05.023
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发表时间：
2017-04-01
影响因子：
5
通讯作者：
Mosca, Andrea
中科院分区：
文献类型：
--
作者：
Paleari, Renata;Caruso, Donatella;Mosca, Andrea
血红蛋白A（2）（HbA（2））作为S-地中海贫血存在的指标的重要性是多年前建立的。然而，由于方法和实验室之间的HbA（2）结果等效性较差，推荐的HbA（2）临界值的临床应用往往受到阻碍。因此，IFCC于2004年启动了HbA（2）标准化计划，目标是为该被测物建立一个完整的参考系统。HbA（2）标准化工作仍在进行中，包括开发高阶HbA（2）参考测量程序，以及与IRMM合作制备经认证的参考物质。在这里，我们回顾了HbA（2）标准化的过去，现在和未来，并描述了HbA（2）检测的现状。(C)© 2016 Elsevier B. V.版权所有。
The importance of hemoglobin A(2) (HbA(2)) as an indicator of the presence of S-thalassemia was established many years ago. However, clinical application of recommended HbA(2) cut off values is often hampered due to poor equivalence of HbA(2) results among methods and laboratories. Thus, the IFCC standardization program for HbA(2) was initiated in 2004 with the goal of achieving a complete reference system for this measurand. HbA(2) standardization efforts are still in progress, including the development of a higher-order HbA(2) reference measurement procedure and the preparation of a certified reference material in collaboration with the IRMM. Here, we review the past, present and future of HbA(2) standardization and describe the current status of HbA(2) testing. (C) 2016 Elsevier B.V. All rights reserved.