Increased risk for coeliac disease in paediatric patients with migraine
Increased risk for coeliac disease in paediatric patients with migraine
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DOI：
10.1111/j.1468-2982.2008.01630.x
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发表时间：
2008-09-01
期刊：
影响因子：
4.9
通讯作者：
Cemil, T.
中科院分区：
文献类型：
--
作者：
Alehan, F.;Ozcay, F.;Cemil, T.
目的是为了确定偏头痛儿童患者中乳糜泻(CD)的患病率。对73例6~17岁偏头痛患者和147例正常对照的血清组织转谷氨酰胺酶IgA(TTGA)抗体和血清IgA水平进行了测定。TTGA抗体阳性的患者接受了双腔活检术。研究组tTGA抗体滴度阳性4例(5.5%)，对照组1例(0.6%)(P<；0.05)。三名偏头痛患者的双侧组织学正常，被认为是潜在的CD。研究组和对照组分别有一名患者和一名对照组患者拒绝接受活检。TTGA抗体被认为是CD存在的可靠指标。然而，一些抗体阳性的患者最初可能有正常的活检，并被归类为有潜在的CD。我们发现在儿童偏头痛患者中tTGA抗体的发生率较高，这表明偏头痛与CD之间可能存在关联。
The aim was to determine the prevalence of coeliac disease (CD) in paediatric patients with migraine. Serum tissue transglutaminase IgA (tTGA) antibodies and IgA concentrations were measured in 73 patients with migraine (age range 6-17 years) and the control group (n = 147). Patients having positive tTGA antibodies underwent duedonal biopsy. Four patients (5.5%) from the study group and one (0.6%) from the control group had positive tTGA antibody titres (P < 0.05). Three patients with migraine had normal duedonal histology and were considered as potential CD. One patient from the study group and one from the control group declined to have biopsy. tTGA antibody is considered as a reliable indicator for the presence of CD. However, some patients with positive antibodies may have normal biopsy initially and are classified as having potential CD. Our finding of a higher prevalance of tTGA antibodies in paediatric migraine patients suggests that an association between migraine and CD might exist.