Experiments showing that electromagnetic fields can be used to treat inflammatory diseases.
Experiments showing that electromagnetic fields can be used to treat inflammatory diseases.
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发表时间：
2000
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通讯作者：
G. Nindl;W. Balcavage;D. Vesper;J. Swez;B. Wetzel;J. Chamberlain;M. T. Fox
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文献类型：
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作者：
G. Nindl;W. Balcavage;D. Vesper;J. Swez;B. Wetzel;J. Chamberlain;M. T. Fox
虽然众所周知，电磁场（EMF）可以诱导非愈合性骨折的修复，但EMF治疗仍然局限于骨科诊所，主要是因为治疗的生物和物理机制尚不清楚。然而，人们普遍认为，非侵入性的EMF治疗可能具有广泛的，尽管目前尚未认识到的临床潜力。为了支持这一观点，我们报告说，0.1 mT，60 Hz的电磁场诱导抗CD 3抗体结合T细胞受体（TcRs）的Jurkat细胞，T淋巴细胞系的平均增加20%。此外，我们表明，60 Hz正弦电磁场和商业骨愈合电磁场调节信号转导途径，调节淋巴细胞增殖，通常是通过激活Jurkat TcR触发。当供体动物暴露于骨愈合场（21天，4小时/天）时，在培养物中暴露于EMF的人外周血淋巴细胞（hPBL）和大鼠PBL中显示出类似的EMF效应。虽然我们还没有令人满意地了解我们在细胞和动物实验中获得的差异，我们的研究结果清楚地表明，电磁场可以调节淋巴细胞增殖在体外和体内。由于T细胞是炎症的关键调节剂，因此可以预期开发基于EMF的治疗装置来调节其活性，以提供治疗许多人类炎性疾病如牛皮癣和关节炎的重要工具。
While it is well known that electromagnetic fields (EMFs) can induce repair of non-healing bone fractures, EMF therapy remains confined to orthopedic clinics mainly because the biological and physical mechanisms underlying the therapy are unknown. However, it is generally believed that non-invasive, EMF therapy might have a broad, albeit currently unrecognized clinical potential. In support of this view, we report that 0.1 mT, 60 Hz EMFs induce a 20% mean-increase in anti-CD3 binding to T cell receptors (TcRs) of Jurkat cells, a T lymphocyte cell line. Additionally, we show that 60 Hz sinusoidal EMFs and a commercial bone healing EMF modulate signal transduction pathways that regulate lymphocyte proliferation and that are normally triggered by activating the Jurkat TcR. Similar EMF effects are shown in human peripheral blood lymphocytes (hPBLs), exposed to EMFs in culture and in rat PBLs, when donor animals are exposed to a bone healing field (21 days, 4 hr/day). Although we do not yet satisfactorily understand the differences we obtain in cell and animal based experiments, our findings clearly demonstrate that EMFs can regulate lymphocyte proliferation in vitro and in vivo. Since T cells are key modulators of inflammation, the development of EMF based therapeutic devices to regulate their activity can be expected to provide important tools to treat numerous human inflammatory diseases such as psoriasis and arthritis.