Case of spinocerebellar ataxia type 1 showing high intensity lesions in the frontal white matter on T2-weighted magnetic resonance images.
Case of spinocerebellar ataxia type 1 showing high intensity lesions in the frontal white matter on T2-weighted magnetic resonance images.
复制标题
1 型脊髓小脑共济失调病例在 T2 加权磁共振图像上显示额叶白质有高强度病变。
作者：
T. Nakayama;K. Nakayama;Y. Takahashi;K. Ohkubo;H. Tobe;M. Soma;Y. Ozawa;K. Kanmatsuse;M. Nakamura;T. Hironaga;Y. Makizumi;H. Nagura
我们报告一例遗传学证实的脊髓小脑性共济失调1型（SCA 1），磁共振成像（MRI）显示高信号强度的T2加权像的白色物质的额叶。患者是一名60岁的日本男性，主诉步态不稳和言语困难。他在46岁时被诊断为脊髓小脑共济失调。患者的CAG重复次数为48/26。脑MRI显示小脑和脑干明显萎缩。在T2加权MRI上，额叶白色物质中的高信号强度病变在脑室周围区域明显。此类MRI异常在SCA 1中以前未描述。
We report a case of genetically confirmed spinocerebellar ataxia type 1 (SCA1) in which magnetic resonance imaging (MRI) demonstrated a high signal intensity on T2-weighted images in the white matter of the frontal lobes. The patient was a 60-year-old Japanese man who complained of gait instability and speech difficulties. He was diagnosed as having spinocerebellar ataxia at the age of 46. A CAG repeat number of the patient was 48/26. Brain MRI showed marked atrophy of the cerebellum and brain stem. The high-signal intensity lesions on T2-weighted MRI in the white matter of the frontal lobes were evident in the periventricular regions. Such MRI abnormalities have not been described in SCA1 previously.