Comparative ultrastructure of cellular junctions in working myocardium and the conduction system under normal and pathologic conditions.
Comparative ultrastructure of cellular junctions in working myocardium and the conduction system under normal and pathologic conditions.
复制标题
正常和病理条件下工作心肌和传导系统细胞连接的超微结构比较。
DOI：
10.1016/0022-2828(71)90031-9
复制
发表时间：
1971
影响因子：
5
通讯作者：
T. James
中科院分区：
文献类型：
--
作者：
K. Kawamura;T. James
本文综述了工作心肌和传导系统中肌细胞连接的比较超微结构。在这两种肌肉中，细胞连接可分为四种类型：连接区、桥粒、筋膜粘附区和未分化区。连接点最初被解释为熔合膜，现在被重新定义为缝隙连接。在工作肌的细胞连接(间盘)中，横节主要由大的筋膜粘连占据，纵节有大的神经节，未分化的区域较小。窦房结和动-室结除具有独特的细胞间排列外，还具有细胞连接的特点，在这些细胞连接中，神经节和筋膜粘连较少，体积较小，未分化的区域通常很广泛。浦肯野纤维的细胞连接是偶趾关节病的特征，这是由于大细胞、小而罕见的筋膜粘连以及大而频繁的连接和未分化区域的多面体相互连接所致。在其他动物物种中，浦肯野细胞连接非常类似于工作肌肉的间盘，但它们的盘不是横向逐步地横跨纤维，而是它们的圆盘通常斜向纤维轴。本文还对某些心脏疾病和实验条件下发生的间盘解离的几种模式进行了综述。讨论了工作心肌与传导系统肌细胞连接的超微结构差异的功能意义以及间盘的裂开过程。
The comparative ultrastructure of muscle cell junctions in the working myocardium and conduction system is reviewed. In both kinds of muscles, the cell junction may be divided into four types of regions: the nexuses, the desmosomes, the fasciae adherentes and the undifferentiated regions. The nexus, originally interpreted as a fused membrane, has now been redefined as a gap junction. In the cell junctions (intercalated disks) of working muscle, the transverse segments are chiefly occupied by large fasciae adherentes, the longitudinal segments are provided with large nexuses, and the undifferentiated regions are much less extensive. In addition to their distinctive intercellular arrangement, the sinus node and arterioventricular node are characterized by cell junctions in which nexuses and fasciae adherentes are infrequent and of small size, and the undifferentiated regions are often extensive. The cell junctions of the Purkinje fibers are characteristic in theArtiodactylabecause of polyhedral interconnections of large cells, small and infrequent fasciae adherentes, and large and frequent nexuses and undifferentiated regions. In other animal species, the Purkinje cell junctions rather resemble the intercalated disks of working muscle, but instead of crossing the fiber transversely stepwise, their disks often course obliquely to the fiber axis. Several patterns of dissociation of the intercalated disks which take place in some heart diseases and experimental conditions are also reviewed. The functional implication of the ultrastructural difference in muscle cell junctions between working myocardium and conduction system and the dehiscence processes of the intercalated disks are discussed.