Long-term object location memory in rats: Effects of sample phase and delay length in spontaneous place recognition test
Long-term object location memory in rats: Effects of sample phase and delay length in spontaneous place recognition test
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DOI：
10.1016/j.neulet.2011.04.022
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发表时间：
2011-06-15
影响因子：
2.5
通讯作者：
Ichitani, Yukio
中科院分区：
文献类型：
--
作者：
Ozawa, Takaaki;Yamada, Kazuo;Ichitani, Yukio
本研究探讨了样本相位和延迟长度对大鼠自发位置再认（SPR）实验中辨别能力的影响。允许大鼠探索竞技场，其中呈现两个相同的物体5-20分钟（样品阶段）。在延迟间隔后，将大鼠再次放置在相同的竞技场中，但将两个物体中的一个移动到新的位置（测试阶段）。结果表明，当取样期长达20 min时，即使延迟6-24 h，大鼠在测试期仍优先探索移动物体。进一步的顺序和累积分析的测试阶段显示，在一个新的地方的对象的偏好是显而易见的，在第一和第2分钟的测试阶段，在大鼠具有较长的样本阶段持续时间。相关分析表明，在样本阶段的自发活动和物体探索不是空间记忆成绩的决定性因素。目前的结果表明，样品相曝光时间和测试相长度的重要性。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
This study investigates the effects of sample phase and delay length on discrimination performance in the spontaneous place recognition (SPR) test in rats. Rats were allowed to explore an arena where two identical objects were presented for 5-20 min (sample phase). After a delay interval, rats were placed again in the same arena but one of the two objects was moved to a novel place (test phase). Results showed that when the sample phase was as long as 20 min, rats preferentially explored the moved object during the test phase even after a 6-24 h delay was interposed. Further sequential and cumulative analyses of the test phase revealed that the preference for the object in a novel place was evident in the first and 2nd min of the test phase in rats with a longer sample phase duration. Correlation analysis showed that locomotor activity and object exploration in the sample phase were not decisive factors in spatial memory performance. The present results demonstrate the importance of the sample phase exposure time and the test phase length. (C) 2011 Elsevier Ireland Ltd. All rights reserved.