The SLC31 (Ctr) copper transporter family
The SLC31 (Ctr) copper transporter family
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DOI：
10.1007/s00424-003-1092-1
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发表时间：
2004-02-01
影响因子：
4.5
通讯作者：
Petris, MJ
中科院分区：
文献类型：
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作者：
Petris, MJ
铜对于许多铜依赖性过程至关重要，包括线粒体氧化磷酸化、自由基解毒、色素沉着、神经递质合成和铁代谢。高亲和力铜摄取和输出蛋白质的鉴定极大地扩展了我们对细胞铜稳态的理解。人体细胞中的铜输出是由 ATP7A 和 ATP7B P 型 ATP 酶介导的，它们分别受到铜代谢遗传性疾病、门克斯病和威尔逊病的影响。称为 SLC31 或 Ctr 蛋白家族的不同类别的转运蛋白介导细胞铜的吸收。这些高亲和力的铜转运蛋白存在于所有真核生物中，它们的发现为细胞如何获取和调节这种必需营养素提供了新的见解。以下是 SLC31 铜转运蛋白家族的简要概述，重点关注人类 hCtr1 蛋白。
Copper is essential for many copper-dependent processes, including mitochondrial oxidative phosphorylation, free-radical detoxification, pigmentation, neurotransmitter synthesis, and iron metabolism. The identification of proteins for high affinity copper uptake and export has greatly expanded our understanding of cellular copper homeostasis. Copper export in human cells is mediated by the ATP7A and ATP7B P-type ATPases, which are, respectively, affected in the genetic disorders of copper metabolism, Menkes disease and Wilson disease. A different class of transporter known as the SLC31 or Ctr family of proteins mediates cellular copper uptake. These high-affinity copper transporters exist in all eukaryotes and their discovery has provided new insights into how cells acquire and regulate this essential nutrient. The following is a brief overview of the SLC31 copper transporter family with a focus on the human hCtr1 protein.