The origin of fibrogenic myofibroblasts in fibrotic liver.
The origin of fibrogenic myofibroblasts in fibrotic liver.
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DOI：
10.1002/hep.28948
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发表时间：
2017-03
期刊：
影响因子：
--
通讯作者：
Kisseleva T
中科院分区：
文献类型：
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作者：
Kisseleva T
肝纤维化是由不同病因的慢性肝损伤引起的。其特征在于生理重塑的失调、肌成纤维细胞的活化和纤维性瘢痕的形成。肌成纤维细胞产生收缩功能并分泌形成纤维性瘢痕的细胞外基质蛋白。肌成纤维细胞不存在于正常肝脏中，但在损伤和炎症时激活和增殖。本文就肝纤维化中细胞群对肌成纤维细胞的作用的认识和争议作一综述。
Liver fibrosis results from chronic liver injury of different etiologies. It is characterized by dysregulation of physiological remodeling, activation of myofibroblasts, and formation of a fibrous scar. Myofibroblasts develop contractile functions and secrete the extracellular matrix proteins that form this fibrous scar. Myofibroblasts are not present in the normal liver but activate and proliferate in response to injury and inflammation. This review summarizes the understanding and controversies on the contribution of cell populations to the myofibroblasts in liver fibrosis.