T1-Weighted MRI Shows Stage-Dependent Substantia Nigra Signal Loss in Parkinson's Disease
T1-Weighted MRI Shows Stage-Dependent Substantia Nigra Signal Loss in Parkinson's Disease
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DOI：
10.1002/mds.23722
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发表时间：
2011-08-01
影响因子：
8.6
通讯作者：
Auer, Dorothee P.
中科院分区：
文献类型：
--
作者：
Schwarz, Stefan T.;Rittman, Timothy;Auer, Dorothee P.
黑质色素脱失是帕金森病的一个显著病理特征，与神经黑色素的丢失有关。与黑色素类似，神经黑色素具有顺磁性，导致特定T1加权磁共振成像信号增加。本研究的目的是使用优化的神经黑素敏感T1扫描评估帕金森病患者黑质的信号变化。10例帕金森病患者和12名匹配的对照者进行了3 T磁化传递效应的高分辨率T1加权磁共振成像。以信号强度高于背景信号强度的像素数+ 3个标准差和区域对比度确定黑质核部的大小和信号强度。使用统一帕金森病评定量表和Hoehn和Yahr帕金森病分期量表将患者细分为早期（n = 6）和晚期（n = 4）。与对照组相比，患者黑质的T1高信号区明显较小（-60%，P < .01），对比度降低（-3%，P < .05）。在更晚期的疾病（-78%）中，尺寸减小甚至比在早期疾病（-47%）中更明显。我们目前的初步研究结果，使用改进的T1加权磁共振成像技术显示阶段依赖性黑质信号减少帕金森氏病作为一个假定的标志物的神经黑色素损失。我们的数据表明，减少在大小的神经黑素丰富的黑质相关以及与死后观察多巴胺能神经元的损失。进一步验证我们的结果可能会导致帕金森病疾病进展的新生物标志物的开发。(C)2011年运动障碍学会
Depigmentation of the substantia nigra is a conspicuous pathological feature of Parkinson's disease and related to a loss of neuromelanin. Similar to melanin, neuromelanin has paramagnetic properties resulting in signal increase on specific T1-weighted magnetic resonance imaging. The aim of this study was to assess signal changes in the substantia nigra in patients with Parkinson's disease using an optimized neuromelanin-sensitive T1 scan. Ten patients with Parkinson's disease and 12 matched controls underwent high-resolution T1-weighted magnetic resonance imaging with magnetization transfer effect at 3T. The size and signal intensity of the substantia nigra pars compacta were determined as the number of pixels with signal intensity higher than background signal intensity + 3 standard deviations and regional contrast ratio. Patients were subclassified as early stage (n = 6) and late stage (n = 4) using the Unified Parkinson's Disease Rating Scale and the Hoehn and Yahr Parkinson's disease staging scale. The T1 hyperintense area in the substantia nigra was substantially smaller in patients compared with controls (-60%, P < .01), and contrast was reduced (-3%, P < .05). Size reduction was even more pronounced in more advanced disease (-78%) than in early-stage disease (-47%). We present preliminary findings using a modified T1-weighted magnetic resonance imaging technique showing stage-dependent substantia nigra signal reduction in Parkinson's disease as a putative marker of neuromelanin loss. Our data suggest that reduction in the size of neuromelanin-rich substantia nigra correlates well with postmortem observations of dopaminergic neuron loss. Further validation of our results could potentially lead to development of a new biomarker of disease progression in Parkinson's disease. (C) 2011 Movement Disorder Society