Peptide-based fibrin-targeting probes for thrombus imaging.
Peptide-based fibrin-targeting probes for thrombus imaging.
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DOI：
10.1039/c7dt02634j
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发表时间：
2017-10-31
期刊：
影响因子：
--
通讯作者：
Caravan P
中科院分区：
文献类型：
--
作者：
Oliveira BL;Caravan P
The development of new methods to image the onset and progression of thrombosis is an unmet need. Non-invasive molecular imaging techniques targeting specific key structures involved in the formation of thrombosis have demonstrated the ability to detect thrombus in different disease state models and in patients. Due to its high concentration in the thrombus and its essential role in thrombus formation, the detection of fibrin is an attractive strategy for identification of thrombosis. Herein we provide an overview of recent and selected fibrin-targeted probes for molecular imaging of thrombosis by magnetic resonance imaging (MRI), positron emission tomography (PET), single photon emission computed tomography (SPECT), and optical techniques. Emphasis is placed on work that our lab has explored over the last 15 years that has resulted in the progression of the fibrin-binding PET probe [64Cu]FBP8 from preclinical studies into human trials. Herein we provide an overview of peptide-based fibrin-targeted probes developed for molecular imaging of thrombosis by different modalities with particular emphasis for nuclear imaging techniques.
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影响因子：
14
作者：
Hara, Tetsuya;Bhayana, Brijesh;Thompson, Brian;Kessinger, Chase W.;Khatri, Ashok;McCarthy, Jason R.;Weissleder, Ralph;Lin, Charles P.;Tearney, Guillermo J.;Jaffer, Farouc A.
通讯作者：
Jaffer, Farouc A.
MR成像探针：设计和应用。
DOI：
10.1039/c4dt02958e
发表时间：
2015-03-21
期刊：
Dalton transactions (Cambridge, England : 2003)
影响因子：
--
作者：
Boros E;Gale EM;Caravan P
通讯作者：
Caravan P
影响因子：
4.9
作者：
Ciesienski KL;Yang Y;Ay I;Chonde DB;Loving GS;Rietz TA;Catana C;Caravan P
通讯作者：
Caravan P
影响因子：
8.3
作者：
Haeusler, Karl Georg;Wollboldt, Christian;Fiebach, Jochen B.
通讯作者：
Fiebach, Jochen B.
DOI：
10.1161/atvbaha.113.302931
发表时间：
2014-06
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Andia ME;Saha P;Jenkins J;Modarai B;Wiethoff AJ;Phinikaridou A;Grover SP;Patel AS;Schaeffter T;Smith A;Botnar RM
通讯作者：
Botnar RM