c-erbB-2 oncoprotein and epidermal growth factor receptor in cervical lesions
c-erbB-2 oncoprotein and epidermal growth factor receptor in cervical lesions
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DOI：
10.1159/000164118
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发表时间：
1997-05-01
期刊：
影响因子：
5
通讯作者：
Pillai, MR
中科院分区：
文献类型：
--
作者：
Lakshmi, S;Nair, MB;Pillai, MR
表皮生长因子受体(EGF-R)及其癌基因产物c-erbB-2已被证明在人类肿瘤中表达，在某些情况下与临床预后有关。本研究调查这些受体蛋白的存在与宫颈组织的不同组织学分级之间的相关性。免疫细胞化学结果显示，宫颈良性、癌前和恶性组织中这两种蛋白的表达与宫颈病变的组织学分级有高度相关性。此外，这些蛋白的总体共表达频率是相似的。这项研究表明，这些蛋白可能参与了细胞的增殖，并在宫颈癌的进展中发挥了重要作用。
Epidermal growth factor receptor (EGF-R) and the oncogene product of c-erbB-2 have been shown to be expressed in human tumors and in some cases relate to clinical outcome. This study investigates the correlation between the presence of these receptor proteins and various histological grades of cervical tissues. Imunocytochemical analysis of benign, premalignant and malignant cervical tissues showed a highly significant correlation between the expression of the two proteins and the histological grade of the lesions. Moreover, the overall frequency of coexpression of these proteins was similar. This study suggests that these proteins may be involved in cellular proliferation and have a significant role in the progression of cervical cancer.