Expression of GP88 (progranulin) in serum of prostate cancer patients is associated with Gleason scores and overall survival
Expression of GP88 (progranulin) in serum of prostate cancer patients is associated with Gleason scores and overall survival
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DOI：
10.2147/cmar.s172069
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发表时间：
2018-01-01
影响因子：
3.3
通讯作者：
Lieb, Verena
中科院分区：
文献类型：
--
作者：
Greither, Thomas;Fischer, Kersten;Lieb, Verena
背景资料：GP 88/颗粒蛋白原是一种公认的细胞生长促进剂在不同的癌症，血清GP 88水平升高已被描述为乳腺癌的负面预后因素。然而，血清水平在前列腺癌（PCa）patients.Material和方法：我们分析了血清GP 88水平的酶免疫吸附试验，并与PCa患者的临床病理参数。根据血清GP 88中位水平（低44.56 ng/mL）和中位年龄（年轻66岁）将PCa患者分为两组。结果：血清GP 88低水平在年轻患者中更常见，而高水平在老年患者中更常见（P=0.018; Fisher精确检验）。PCa患者分为三组，Gleason评分（GS）= 8。在受试者工作特征分析中，我们可以区分GS = 8。对于存活分析，通过36.92 ng/mL的优化截止值将GP 88水平分成两组。使用此GP 88分层，所有PCa患者和年轻患者血清GP 88水平较低的患者有更好的总生存期与血清GP 88水平较高的患者相比（对数秩检验P=0.010和P=0.024）。结论：血清GP 88水平是显着不同的年龄和GS，他们与PCa患者的预后。
Background: GP88/Progranulin is a well-recognized cell growth promoter in different cancers, and elevated serum GP88 levels have been described as negative prognostic factor in breast cancer. However, serum levels in prostate cancer (PCa) patients have not yet been studied.Material and Methods: We analyzed serum GP88 levels by enzyme immunosorbent assay and correlated them with clinicopathological parameters in PCa patients. PCa patients were separated into two groups based on the serum GP88 median level (low 44.56 ng/mL) and according to their median age (younger 66 years).Results: Low serum GP88 levels were more often detected in younger patients and high levels in elder patients (P=0.018; Fisher's exact test). PCa patients were separated into three groups, Gleason score (GS) = 8. In receiver operating characteristic analyses, we could distinguish GS = 8. For survival analysis, GP88 levels were separated into two groups by an optimized cutoff value of 36.92 ng/mL. Using this GP88 stratification, all PCa patients and younger patients with a low serum GP88 level had a significantly better overall survival compared with patients with higher serum GP88 levels (log-rank test P=0.010 and P=0.024).Conclusion: Serum GP88 levels are significantly different depending on age and GS, and they are associated with the prognosis of PCa patients.