Disturbances in social interaction occur along with pathophysiological deficits following sub-chronic phencyclidine administration in the rat
Disturbances in social interaction occur along with pathophysiological deficits following sub-chronic phencyclidine administration in the rat
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DOI：
10.1016/j.bbr.2008.07.020
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发表时间：
2008-12-12
影响因子：
2.7
通讯作者：
Reynolds, Gavin P.
中科院分区：
文献类型：
--
作者：
Jenkins, Trisha A.;Harte, Michael K.;Reynolds, Gavin P.
亚慢性给大鼠服用苯环利定会导致持久的病理、生理和认知变化，这些变化类似于精神分裂症的某些特征。本研究旨在确定这种苯环利定疗法的行为后果是否延伸到社会互动的长期中断，这可能与疾病的一些负面症状平行。给予苯环利定(2 mg/kg，2次/d，连续1周)或赋形剂，然后停药一段时间。分别于治疗后24小时、1周、3周、6周进行社会交往评定。在苯环利定组中观察到了一种长期的社会行为干扰，即在所有时间点都与陌生的靶鼠进行了更多的接触和非接触互动。苯环利定用药6周后，对大脑的分析显示，海马区小白蛋白免疫反应神经元的表达减少，其中显著减少的部位位于CA1区和齿状回。这些结果表明，亚慢性苯环利定会在社交互动中产生长期的干扰，但并不能模拟精神分裂症患者的社交退缩。这些社会行为的干扰可能与同时发生的大脑病理生理变化有关。(C)2008爱思唯尔B.V.保留所有权利。
A sub-chronic administration of phencyclidine to the rat brings about enduring pathophysiological and cognitive changes that resemble some features of schizophrenia. The present study aimed to determine whether the behavioural consequence of this phencyclidine regime extends to a long-term disruption of social interaction that might provide a parallel with some negative symptoms of the disease. Rats were treated with phencyclidine (2 mg/kg bi-daily for 1 week) or vehicle followed by a drug-free period. Social interaction was assessed 24 h, 1 week, 3 weeks and 6 weeks post-treatment. A long-lasting disturbance of social behaviour was observed in the phencyclidine group, namely more contact and non-contact interaction with an unfamiliar target rat at all time points. Six weeks post-phencyclidine, analysis of brains showed a reduction in expression of parvalbumin immunoreactive neurons in the hippocampus with significant reductions localised to the CA1 and dentate gyrus regions. These results show that sub-chronic phencyclidine produces long-lasting disruptions in social interaction that, however, do not model the social withdrawal seen in patients with schizophrenia. These disturbances of social behaviour may be associated with concurrent pathophysiological brain changes. (C) 2008 Elsevier B.V. All rights reserved.