Mechano-Responsive Hydrogels Crosslinked by Block Copolymer Micelles.
Mechano-Responsive Hydrogels Crosslinked by Block Copolymer Micelles.
复制标题
DOI：
10.1039/c2sm26566d
复制
发表时间：
2012-10-28
期刊：
影响因子：
3.4
通讯作者：
Jia X
中科院分区：
文献类型：
--
作者：
Xiao L;Zhu J;Londono DJ;Pochan DJ;Jia X
以丙烯酸羟乙酯部分改性聚丙烯酸和聚丙烯酸丁酯的两亲嵌段共聚物，制备了嵌段共聚胶束(BCMS)。丙烯酰胺在胶束交联剂存在下的自由基聚合形成了弹性水凝胶(BCM-PAAM)，其力学性能可以通过改变BCM的组成来调节。透射电子显微镜(TEM)成像显示BCM-PAAM凝胶中拉伸诱导的可逆胶束变形。在BCM-PAAM凝胶形成之前加载到胶束核心中的模型疏水药物芘在外部施加的机械力的响应下被动态释放。BCM-交联型水凝胶具有结合强度和力调节药物释放的特点，是机械活性组织修复和再生的候选材料。
Block copolymer micelles (BCMs) were prepared from amphiphilic diblock copolymers of poly(n-butyl acrylate) and poly(acrylic acid) partially modified with 2-hydroxyethyl acrylate. Radical polymerization of acrylamide in the presence of micellar crosslinkers gave rise to elastomeric hydrogels (BCM-PAAm) whose mechanical properties can be tuned by varying the BCM composition. Transmission electron microscopy (TEM) imaging revealed stretch-induced, reversible micelle deformation in BCM-PAAm gels. A model hydrophobic drug, pyrene, loaded into the micelle core prior to the formation of BCM-PAAm gels, was dynamically released in response to externally applied mechanical forces. The BCM-crosslinked hydrogels with combined strength and force-modulated drug release are attractive candidates for the repair and regeneration of mechanically-active tissues.