Multiple serotonergic brainstem abnormalities in sudden infant death syndrome
Multiple serotonergic brainstem abnormalities in sudden infant death syndrome
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DOI：
10.1001/jama.296.17.2124
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发表时间：
2006-11-01
影响因子：
120.7
通讯作者：
Kinney, Hannah C.
中科院分区：
文献类型：
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作者：
Paterson, David S.;Trachtenberg, Felicia L.;Kinney, Hannah C.
延髓中的血清素能（5-羟色胺 [5-HT]）神经元广泛投射到脑干和脊髓中的自主神经核和呼吸核，帮助调节体内平衡功能。此前，已发现因婴儿猝死综合症 (SIDS) 死亡的婴儿的髓质中 5-HT 受体结合异常，这表明髓质 5-HT 功能障碍可能是造成部分 SIDS 病例的原因。 目的 研究与 SIDS 病例中髓质 5-HT 通路中 5-HT 受体结合改变相关的细胞缺陷。 设计、设置和参与者 1997 年至 2005 年间，从圣地亚哥法医办公室获得因 SIDS（病例）或非 SIDS 原因（对照）而死亡的婴儿的冷冻髓质。比较了 SIDS 病例和对照之间的 5-HT 功能标记，并根据受孕后年龄和死后间隔进行了调整。对于 SIDS 病例，每次分析的可用样本数量为 16 至 31 个，对照样本数量为 6 至 10 个。对标志物与 6 个公认的 SIDS 危险因素之间的相关性进行了探索性分析。主要结果测量髓质 5-HT 系统中的 5-HT 神经元计数和密度、5-HT1A 受体结合密度以及 5-HT 转运蛋白 (5-HTT) 结合密度；这些标志物与 6 个公认的 SIDS 危险因素之间的相关性。 结果 与对照相比，SIDS 病例的 5-HT 神经元计数（平均 [SD]，分别为 148.04 [51.96] 与 72.56 [52.36] 个细胞；P < .001）和 5-HT 神经元密度 (P < .001) 显着较高，5-HT1A 受体密度显着较低 结合位点（P
Context The serotonergic (5-hydroxytryptamine [5-HT]) neurons in the medulla oblongata project extensively to autonomic and respiratory nuclei in the brainstem and spinal cord and help regulate homeostatic function. Previously, abnormalities in 5-HT receptor binding in the medullae of infants dying from sudden infant death syndrome (SIDS) were identified, suggesting that medullary 5-HT dysfunction may be responsible for a subset of SIDS cases.Objective To investigate cellular defects associated with altered 5-HT receptor binding in the 5-HT pathways of the medulla in SIDS cases.Design, Setting, and Participants Frozen medullae from infants dying from SIDS (cases) or from causes other than SIDS (controls) were obtained from the San Diego Medical Examiner's office between 1997 and 2005. Markers of 5-HT function were compared between SIDS cases and controls, adjusted for postconceptional age and postmortem interval. The number of samples available for each analysis ranged from 16 to 31 for SIDS cases and 6 to 10 for controls. An exploratory analysis of the correlation between markers and 6 recognized risk factors for SIDS was performed.Main Outcome Measures 5-HT neuron count and density, 5-HT1A receptor binding density, and 5-HT transporter (5-HTT) binding density in the medullary 5-HT system; correlation between these markers and 6 recognized risk factors for SIDS.Results Compared with controls, SIDS cases had a significantly higher 5-HT neuron count (mean [SD], 148.04 [51.96] vs 72.56 [52.36] cells, respectively; P < .001) and 5-HT neuron density (P < .001), as well as a significantly lower density of 5-HT1A receptor binding sites (P