Correlation of MR imaging-determined cerebral blood volume maps with histologic and angiographic determination of vascularity of gliomas
Correlation of MR imaging-determined cerebral blood volume maps with histologic and angiographic determination of vascularity of gliomas
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DOI：
10.2214/ajr.171.6.9843274
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发表时间：
1998-12-01
影响因子：
5
通讯作者：
Takahashi, M
中科院分区：
文献类型：
--
作者：
Sugahara, T;Korogi, Y;Takahashi, M
目标。我们的目的是利用梯度回波平面磁共振成像技术评价脑胶质瘤的最大相对脑血容量(RCBV)比值(rCBV比值=rCBV[肿瘤]/rCBV[对侧白质])与组织学和血管成像的关系。我们还评估了rCBV图对胶质瘤分级的有用性。我们检查了30例经组织学证实的胶质瘤患者。胶质瘤分为胶质母细胞瘤、间变性胶质瘤强化、无强化间变性胶质瘤和低级别胶质瘤。结果：将每个胶质瘤的最大rCBV比率与组织学和血管造影的血管进行比较，并建立了最大rCBV比率与每种胶质瘤类型之间的关系。胶质瘤的最大rCBV比率与组织学和血管造影的血管显著相关(p<；.001)。胶质母细胞瘤、有强化的间变性胶质瘤、无强化的间变性胶质瘤、低级别胶质瘤的rCBV均值和最大rCBV比值分别为7.32+/-4.39、5.84+/-1.82、1.53+/-0.75和1.26+/-0.55。胶质母细胞瘤的最大rCBV比值显著高于无强化的间变性胶质瘤(p=0.002)和低级别胶质瘤(p<；.001)，有强化的间变性胶质瘤的最大rCBV比值高于无强化的间变性胶质瘤和低级别胶质瘤，但差异无统计学意义(分别为p=0.08和p=0.03)。
OBJECTIVE. Our purpose was to evaluate the relationships between the ratio of maximum relative cerebral blood volume (rCBV) (rCBV ratio = rCBV[tumor] / rCBV[contralateral white matter]) and histologic and angiographic vascularities of gliomas using the gradient-echo echoplanar MR imaging technique. We also evaluated the usefulness of rCBV maps for grading gliomas.SUBJECTS AND METHODS. We examined 30 patients with histologically verified gliomas. Gliomas were classified as glioblastoma, anaplastic glioma with enhancement, anaplastic glioma without enhancement, and low-grade glioma. The maximum rCBV ratio of each glioma was compared with both histologic and angiographic vascularities, and the relationship between the maximum rCBV ratios and each type of glioma was established,RESULTS. The maximum rCBV ratios of the gliomas significantly correlated with both histologic and angiographic vascularities (p < .001). Mean values and SDs of maximum rCBV ratios of each type of tumor were 7.32 +/- 4.39 for glioblastomas, 5.84 +/- 1.82 for anaplastic gliomas with enhancement, 1.53 +/- 0.75 for anaplastic gliomas without enhancement, and 1.26 +/- 0.55 for low-grade gliomas. The maximum rCBV ratios of the glioblastomas were significantly higher than those of the anaplastic gliomas without enhancement (p =.002) and the low-grade gliomas (p < .001), The maximum rCBV ratios of the anaplastic gliomas with enhancement were higher than those of the anaplastic gliomas without enhancement and the low-grade gliomas, but the differences were not statistically significant (p =.08 and p = .03, respectively).CONCLUSION. The results of perfusion-sensitive MR imaging with gradient-echo echoplanar technique correlated with both histologic and angiographic vascularities.