ULTRASTRUCTURAL-CHANGES IN THE BRAIN OF MICE GIVEN CLOSTRIDIUM-PERFRINGENS TYPE-D EPSILON TOXIN
ULTRASTRUCTURAL-CHANGES IN THE BRAIN OF MICE GIVEN CLOSTRIDIUM-PERFRINGENS TYPE-D EPSILON TOXIN
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DOI：
10.1016/0021-9975(84)90031-8
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发表时间：
1984-01-01
影响因子：
0.8
通讯作者：
FINNIE, JW
中科院分区：
文献类型：
--
作者：
FINNIE, JW
给小鼠注射致死和亚致死剂量的C。结果表明，D型产气荚膜杆菌毒素对小鼠脑组织的毒性作用明显，并在30 min ~ 6 h内观察到了早期脑组织的形态学变化。最初的超微结构发现是星形胶质细胞肿胀，尤其是这些细胞的血管周围延伸。小脑中的星形胶质细胞似乎对这种毒素特别敏感。这些变化之后很快出现严重内皮损伤的证据，内皮细胞质变薄、空泡化和电子密度非常高。一个致病序列的事件导致软化，来自超微结构的观察，提出。
Mice were given lethal and sublethal doses of C. perfringens Type D epsilon toxin and the early morphological changes in perfusion-fixed intoxicated brains were examined from 30 min-6 h postinoculation. The initial ultrastructural finding was swelling of astrocytes, especially, the perivascular extensions of these cells. Astrocytes in the cerebellum appeared to be particularly sensitive to this toxin. These changes were quickly followed by evidence of severe endothelial damage, with the endothelial cytoplasm becoming attenuated, vacuolated and very electron-dense. A pathogenetic sequence of events leading to malacia, derived from ultrastructural observations, is proposed.