Assessment of Gastrointestinal Autonomic Dysfunction: Present and Future Perspectives.
Assessment of Gastrointestinal Autonomic Dysfunction: Present and Future Perspectives.
复制标题
胃肠自主神经功能障碍的评估：现在和未来的观点。
DOI：
10.3390/jcm10071392
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发表时间：
2021-03-31
影响因子：
3.9
通讯作者：
Krogh K
中科院分区：
文献类型：
--
作者：
Kornum DS;Terkelsen AJ;Bertoli D;Klinge MW;Høyer KL;Kufaishi HHA;Borghammer P;Drewes AM;Brock C;Krogh K
The autonomic nervous system delicately regulates the function of several target organs, including the gastrointestinal tract. Thus, nerve lesions or other nerve pathologies may cause autonomic dysfunction (AD). Some of the most common causes of AD are diabetes mellitus and α-synucleinopathies such as Parkinson’s disease. Widespread dysmotility throughout the gastrointestinal tract is a common finding in AD, but no commercially available method exists for direct verification of enteric dysfunction. Thus, assessing segmental enteric physiological function is recommended to aid diagnostics and guide treatment. Several established assessment methods exist, but disadvantages such as lack of standardization, exposure to radiation, advanced data interpretation, or high cost, limit their utility. Emerging methods, including high-resolution colonic manometry, 3D-transit, advanced imaging methods, analysis of gut biopsies, and microbiota, may all assist in the evaluation of gastroenteropathy related to AD. This review provides an overview of established and emerging assessment methods of physiological function within the gut and assessment methods of autonomic neuropathy outside the gut, especially in regards to clinical performance, strengths, and limitations for each method.
