Xenogeneic Lung Transplantation Models
Xenogeneic Lung Transplantation Models
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DOI：
10.1007/978-1-0716-0255-3_12
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发表时间：
2020-01-01
期刊：
影响因子：
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通讯作者：
Pierson, Richard N., III
中科院分区：
文献类型：
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作者：
Burdorf, Lars;Azimzadeh, Agnes M.;Pierson, Richard N., III
肺异种移植的研究已被证明有助于了解其他器官异种移植成功移植的剩余障碍。本章将简要回顾异种肺移植的历史和现状，并介绍两种不同的实验模型：离体猪到人肺灌流和体内异种肺移植。我们将充分详细地关注这些肺异种移植模型的技术细节，列出所需的材料，并提及分析技术，以允许其他人以最小的学习曲线采用它们。
Study of lung xenografts has proven useful to understand the remaining barriers to successful transplantation of other organ xenografts. In this chapter, the history and current status of lung xenotransplantation will be briefly reviewed, and two different experimental models, the ex vivo porcine-to-human lung perfusion and the in vivo xenogeneic lung transplantation, will be presented. We will focus on the technical details of these lung xenograft models in sufficient detail, list the needed materials, and mention analysis techniques to allow others to adopt them with minimal learning curve.