Nicotine elicits methamphetamine-seeking in rats previously administered nicotine
Nicotine elicits methamphetamine-seeking in rats previously administered nicotine
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DOI：
10.1016/j.drugalcdep.2009.07.018
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发表时间：
2010-01-01
影响因子：
4.2
通讯作者：
Bardo, M. T.
中科院分区：
文献类型：
--
作者：
Neugebauer, N. M.;Harrod, S. B.;Bardo, M. T.
研究表明，精神兴奋剂的使用与人类物质滥用者吸烟之间存在高度相关性。本研究的目的是在啮齿类动物自我给药模型中检查尼古丁急性和重复给药对静脉注射甲基苯丙胺（0.03 mg/kg/输注）反应的影响，以及尼古丁诱导雄性Sprague-Dawley大鼠恢复先前消退的吸毒行为的潜力。此外，还评估了尼古丁诱导的甲基苯丙胺寻求行为恢复和尼古丁诱导的运动致敏是否需要尼古丁与甲基苯丙胺自我给药阶段或运动活动室暂时配对。尼古丁急剧减少甲基苯丙胺自我管理，但没有持续改变响应甲基苯丙胺自我管理的维护过程中。然而，在甲基苯丙胺自我给药消失后，尼古丁给药仅在先前给予尼古丁的大鼠中恢复了甲基苯丙胺寻求行为。尼古丁诱导的恢复和表达的运动敏化不依赖于时间配对的尼古丁与甲基苯丙胺自我管理会议或运动活动室，分别。这些结果表明，尼古丁可能至少部分地通过非关联机制来恢复甲基苯丙胺寻求行为。(C)2009爱思唯尔爱尔兰有限公司保留所有权利。
Research has indicated a high correlation between psychostimulant use and tobacco cigarette smoking in human substance abusers. The objective of the current study was to examine the effects of acute and repeated nicotine administration on responding for intravenous methamphetamine (0.03 mg/kg/infusion) in a rodent model of self-administration, as well as the potential of nicotine to induce reinstatement of previously extinguished drug-taking behavior in male Sprague-Dawley rats. In addition, it was assessed whether nicotine-induced reinstatement of methamphetamine-seeking behavior and nicotine-induced locomotor sensitization require that nicotine be temporally paired with the methamphetamine self-administration session or the locomotor activity chamber. Nicotine acutely decreased methamphetamine self-administration, but did not persistently alter responding during the maintenance of methamphetamine self-administration. However, following extinction of methamphetamine self-administration, nicotine administration reinstated methamphetamine-seeking behavior only in rats that had previously been administered nicotine. Nicotine-induced reinstatement and expression of locomotor sensitization were not dependent on a temporal pairing of nicotine with either the methamphetamine self-administration session or the locomotor activity chamber, respectively. These results indicate that nicotine may be acting, at least in part, through a non-associative mechanism to reinstate methamphetamine-seeking behavior. (C) 2009 Elsevier Ireland Ltd. All rights reserved.