Age at onset and familial risk in Alzheimer's disease.
Age at onset and familial risk in Alzheimer's disease.
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阿尔茨海默病的发病年龄和家族风险。
DOI：
10.1176/ajp.152.3.424
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Davis,KL
中科院分区：
文献类型：
--
作者：
Li,G;Silverman,JM;Smith,CJ;Zaccario,ML;Schmeidler,J;Mohs,RC;Davis,KL
作者调查了先证者的年龄在阿尔茨海默病发病的关系与先证者的一级亲属的原发性进行性痴呆的风险。MethodTwo hundred probands与临床诊断的阿尔茨海默病和179 nondementid老年先证者被招募从西奈山阿尔茨海默病研究中心，位于西奈山医院和布朗克斯退伍军人事务医疗中心。人口统计学和诊断数据收集了1,398的一级亲属的先证者与阿尔茨海默病和955一级亲属的nondedmented probands.ResultsCox比例风险回归分析显示，在阿尔茨海默病的先证者和更大的家族风险在他们的亲属发病年龄之间显着的反比关系。后续分析表明，最常用的发病年龄截止点-65岁-是最不可能揭示与家族聚集性相关性的点之一;其他发病截止年龄（例如，55，70，和75）更好地确定阿尔茨海默病组与不同的家族/结论作者得出结论，阿尔茨海默病发病年龄较早的患者比发病年龄较晚的患者更有可能有阿尔茨海默病亲属。这种疾病发病年龄为70岁，最佳区分先证者，其亲属的风险较高，而其亲属的风险较低。
ObjectiveThe authors investigated the relationship between probands' age at onset of Alzheimer's disease with the risk of primary progressive dementia in the probands' first-degree relatives.MethodTwo hundred probands with clinically diagnosed Alzheimer's disease and 179 nondemented elderly probands were recruited from the Mount Sinai Alzheimer's Disease Research Center, located at Mount Sinai Hospital and the Bronx Veterans Affairs Medical Center. Demographic and diagnostic data were collected on 1,398 of the first-degree relatives of the probands with Alzheimer's disease and 955 first-degree relatives of the nondemented probands.ResultsCox proportional hazards regression analysis showed a significant inverse relationship between age at onset of Alzheimer's disease in probands and greater familial risk in their relatives. Follow-up analyses indicated that the most commonly used age at onset cutoff point--65 years--was one of the points where an association with familial aggregation is least likely to be revealed; other onset cutoff ages (eg, 55, 70, and 75) better identified Alzheimer's disease groups with differing familial/genetic risks.ConclusionsThe authors conclude that patients with an earlier age at onset of Alzheimer's disease are more likely to have relatives with Alzheimer's disease than are patients with a later age at onset of the disease. An onset age of 70 best differentiated probands whose relatives were at higher risk from those whose relatives were at lower risk.