COMPARISON OF LONG-TERM SYSTEMIC AND SECRETORY ANTIBODY-RESPONSES IN CHILDREN GIVEN LIVE, ATTENUATED, OR INACTIVATED INFLUENZA-A VACCINE
COMPARISON OF LONG-TERM SYSTEMIC AND SECRETORY ANTIBODY-RESPONSES IN CHILDREN GIVEN LIVE, ATTENUATED, OR INACTIVATED INFLUENZA-A VACCINE
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DOI：
10.1002/jmv.1890170405
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发表时间：
1985-01-01
影响因子：
12.7
通讯作者：
WRIGHT, PF
中科院分区：
文献类型：
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作者：
JOHNSON, PR;FELDMAN, S;WRIGHT, PF
在接受初次免疫的幼儿中比较灭活肌内和鼻内甲型流感活疫苗，预计血清和局部粘膜抗体应答可能存在差异。为了证明这种差异，在接种疫苗后一年，检查了接种鼻内甲型流感活疫苗、减毒疫苗、冷适应疫苗（H3N2或H1N1）或肌内灭活疫苗（H3N2）的幼儿的血清和局部呼吸道抗体应答。通过血凝抑制（HAI）和类特异性酶联免疫吸附试验（ELISA）测定抗体应答。接种后一年，鼻内活疫苗与肌内灭活疫苗相比，血清HAI（p = 0.025）和针对流感血凝素和神经氨酸酶的IgG抗体（p = 0.01）的衰减明显更少。鼻分泌伊加几乎完全在活疫苗接种者中发展，并持续长达一年。在活疫苗和灭活疫苗中均检测到持续性鼻分泌IgG。活疫苗接种不仅刺激更持久的血清抗体应答，而且还诱导持久的局部呼吸道伊加抗体，这可能在宿主保护中发挥重要作用。
A comparison of inactivated intramuscular and live intranasal influenza A vaccines in young children undergoing primary immunization might be expected to show differences in serum and local mucosal antibody responses. To demonstrate such differences, serum and local respiratory tract antibody responses of young children vaccinated with intranasal live, attenuated, cold-adapted (H3N2 or H1N1), or intramuscular inactivated (H3N2) influenza A vaccines were examined for one year after vaccination. Antibody responses were measured by hemagglutination-inhibition (HAI) and class-specific enzyme-linked immunosorbent assay (ELISA). One year after vaccination, live intranasal vaccines had significantly less decay of serum HAI (p = 0.025) and IgG antibody (p = 0.01) directed against the influenza hemagglutinin and neuraminidase than did intramuscular inactivated vaccinees. Nasal secretory IgA developed almost exclusively in live vaccinees and persisted for up to one year. Persistent nasal secretory IgG was detected in both live and inactivated vacinees. Live vaccination not only stimulates a more durable serum antibody response, but also induces long-lasting local respiratory tract IgA antibody that may play an important role in host protection.