Nonsteroidal Antiinflammatory Drug-Related Injury to the Gastrointestinal Tract: Clinical Picture, Pathogenesis, and Prevention
Nonsteroidal Antiinflammatory Drug-Related Injury to the Gastrointestinal Tract: Clinical Picture, Pathogenesis, and Prevention
复制标题
DOI：
10.1016/j.gtc.2010.08.010
复制
发表时间：
2010-09-01
影响因子：
3.7
通讯作者：
Hunt, Richard H.
中科院分区：
文献类型：
--
作者：
Scarpignato, Carmelo;Hunt, Richard H.
在发达国家，随着预期寿命的延长，关节炎的发病率越来越高，同时非类固醇抗炎药(NSAIDs)的处方也越来越多。这些都是最广泛使用的肌肉骨骼和关节炎药物。尽管NSAIDs有效，但它们的使用与肝、肾系统、皮肤和肠道(GI)的广泛不良反应有关。副作用最常见。因此，医生开NSAIDs的两难境地是，在保持抗炎和镇痛益处的同时，减少或预防GI副作用。挑战是开发更安全的NSAIDs，从关注GI毒性转向日益受到重视的心血管毒性
Increasing life expectancy in developed countries has led to a growing prevalence of arthritic disorders, which has been accompanied by increasing prescriptions for nonsteroidal antiinflammatory drugs (NSAIDs) These are the most widely used agents for musculoskeletal and arthritic conditions Although NSAIDs are effective, their use is associated with a broad spectrum of adverse reactions in the liver kidney cardiovascular system skin and gut Gastrointestinal (GI) side effects are the most common The dilemma for the physician prescribing NSAIDs is therefore to maintain the antiinflammatory and analgesic benefits while reducing or preventing GI side effects The challenge is to develop safer NSAIDs by shifting from a focus on GI toxicity to the increasingly more appreciated cardiovascular toxicity