Mice without a functional relaxin gene are unable to deliver milk to their pups.
Mice without a functional relaxin gene are unable to deliver milk to their pups.
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DOI：
10.1210/endo.140.1.6404
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发表时间：
1999
期刊：
影响因子：
4.8
通讯作者：
Ling Zhao;Peter J. Roche;Jenny M. Gunnersen;Vicki E. Hammond;Geoffrey W. Tregear;E. Wintour;Felix Beck
中科院分区：
文献类型：
--
作者：
Ling Zhao;Peter J. Roche;Jenny M. Gunnersen;Vicki E. Hammond;Geoffrey W. Tregear;E. Wintour;Felix Beck
我们已经使用基因靶向产生松弛素（rlx）缺陷小鼠。大多数纯合子（rlx-/-）小鼠（17只中有15只）是可育的，产仔正常。然而，他们的乳房发育不足；幼崽不能哺乳，出生后24小时内死亡，除非与野生型（rlx+/+）养母交叉饲养。rlx-/-动物的乳头在怀孕期间不显着扩大，其组织学保持处女状态的外观。即使产奶，足月时乳腺薄壁组织仍未发育完全。这些动物的乳腺导管变得严重扩张。杂合子（rlx+/-）小鼠正常泌乳。rlx-/-小鼠孕期耻骨间韧带不松弛。rlx-/-小鼠妊娠后期血浆渗透压明显高于野生型小鼠（P < 0.001）。
We have used gene targeting to generate relaxin (rlx)-deficient mice. The majority (15 of 17) of homozygous (rlx-/-) mice are fertile and produce normal litters. However their mammary development is deficient; pups are unable to suckle and die within 24 h of birth unless cross-fostered to a wild-type (rlx+/+) foster mother. The nipples of rlx-/- animals do not enlarge significantly during pregnancy, and their histology retains the appearance of the virgin state. Breast parenchyma is somewhat underdeveloped at term even though milk is produced. Mammary ducts become grossly dilated in these animals. Heterozygous (rlx+/-) mice lactate normally. The interpubic ligament does not relax during pregnancy in rlx-/- mice. Plasma osmolality during late gestation was significantly higher (P < 0.001) in rlx-/- mice than in wild-type controls.