Eicosanoid balance and perfusion redistribution of oleic acid-induced acute lung injury.
Eicosanoid balance and perfusion redistribution of oleic acid-induced acute lung injury.
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油酸诱导的急性肺损伤的类二十烷酸平衡和灌注再分配。
DOI：
10.1152/jappl.1992.73.5.2126
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Schuster,DP
中科院分区：
文献类型：
--
作者：
Stephenson,AH;Lonigro,AJ;Holmberg,SW;Schuster,DP
我们已经提出，内源性前列环素对抗血管收缩，该血管收缩导致犬油酸（OA）诱导的急性肺损伤（D. P. Schuster和J. Haller。J.Appl.Physiol.69：353-361，1990）。为了验证这一假设，我们将OA（0.08 ml/kg iv）给药后2.5 h获得的组织样本中6-酮前列腺素（PG）F1 α和血栓烷（Tx）B2的局部肺组织浓度与正电子发射断层扫描测量的rPBF和rLWC相关。仅OA后（n = 16），依赖性肺区域的rLWC增加。一些动物对rLWC增加有反应，rPBF从最水肿的区域重新分布（OA-R，n = 6），而另一些动物则没有反应（OA-NR，n = 10）。在另外6只动物中，在OA（OA-meclo）后给予美克洛酯。OA后，所有组中6-keto-PGF 1 α的组织浓度均高于TxB 2，但OA-R和OA-NR动物之间的6-keto-PGF 1 α浓度无差异。OA-R组和OA-NR组动物依赖区TxB 2均较对照组（n = 4，P < 0.05）升高。对照组和未发生灌注再分布的OA-NR组的组织TxB 2/6-keto-PGF 1 α比值小于发生灌注再分布的OA-R组和OA-meclo组。这种TxB 2/6-keto-PGF 1 α比值与灌注再分布的幅度显著相关。（250字处删节）
We have proposed that endogenous prostacyclin opposes the vasoconstriction responsible for redistribution of regional pulmonary blood flow (rPBF) away from areas of increased regional lung water concentration (rLWC) in canine oleic acid- (OA) induced acute lung injury (D. P. Schuster and J. Haller. J. Appl. Physiol. 69: 353–361, 1990). To test this hypothesis, we related regional lung tissue concentrations of 6-ketoprostaglandin (PG) F1 alpha and thromboxane (Tx) B2 in tissue samples obtained 2.5 h after administration of OA (0.08 ml/kg iv) to rPBF and rLWC measured by positron emission tomography. After OA only (n = 16), rLWC increased in dependent lung regions. Some animals responded to increased rLWC by redistribution of rPBF away from the most edematous regions (OA-R, n = 6), whereas others did not (OA-NR, n = 10). In another six animals, meclofenamate was administered after OA (OA-meclo). After OA, tissue concentrations of 6-keto-PGF1 alpha were greater than TxB2 in all groups, but concentrations of 6-keto-PGF1 alpha were not different between OA-R and OA-NR animals. TxB2 was increased in the dependent regions of animals in both OA-R and OA-NR groups compared with controls (no OA, n = 4, P < 0.05). The tissue TxB2/6-keto-PGF1 alpha ratio was smaller in controls and OA-NR in which no perfusion redistribution occurred than in OA-R and OA-meclo in which it did occur. This TxB2/6-keto-PGF1 alpha ratio correlated significantly with the magnitude of perfusion redistribution.(ABSTRACT TRUNCATED AT 250 WORDS)