Drug permeation through a temperature-sensitive poly(N-isopropylacrylamide) grafted poly(vinylidene fluoride) membrane
Drug permeation through a temperature-sensitive poly(N-isopropylacrylamide) grafted poly(vinylidene fluoride) membrane
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DOI：
10.1016/s0378-5173(97)00384-0
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发表时间：
1998-04-13
影响因子：
5.8
通讯作者：
Paronen, P
中科院分区：
文献类型：
--
作者：
Åkerman, S;Viinikka, P;Paronen, P
聚（N - 异丙基丙烯酰胺）（聚（NIPAAm））是一种温度敏感聚合物，已用于热控装置的开发。在本研究中，通过辐照法制备了聚（NIPAAm）接枝聚偏氟乙烯（PVDF）膜，并测量了模型化合物在各种接枝膜上的通量。以异硫氰酸荧光素 - 葡聚糖（分子量4400 - 50600）和甘露醇作为模型化合物，研究了各种接枝膜通过温度控制药物通量的有效性。此外，还评估了环境条件对膜的最低临界溶液温度（LCST）的影响。温度、环境离子强度和膜的接枝度可有效控制大分子在温度敏感的多孔聚（NIPAAm）- PVDF膜上的通量，而即使在膜接枝度较高的情况下，小分子的通量也不受温度控制。这些结果表明，所研究的膜可用于控制高分子量化合物如多核苷酸、肽和蛋白质的渗透。（C）1998年，爱思唯尔科学出版社。版权所有。
Poly(N-isopropylacrylamide) (poly(NIPAAm)) is a temperature sensitive polymer, which has been used in the development of thermally controlled devices. In the present study, poly(NIPAA)m grafted poly(vinylidene fluoride) (PVDF) membranes were prepared by an irradiation method and fluxes of model compounds across the various grafted membranes were measured. The effectiveness of various grafted membranes to control drug fluxes by temperature was studied using FITC-dextrans (molecular weights 4400-50 600) and mannitol as model compounds. Also, the effect of environmental conditions on the LCST of the membrane was evaluated. The fluxes of bigger molecules across a temperature sensitive, porous poly(NIPAA)m-PVDF membranes were effectively controlled by temperature, environmental ionic strength and degree of grafting of the membrane, while flux of the smaller molecules was not controlled thermally even at high degree of membrane grafting. These result indicates that the studied membranes are useful in controlling the permeation of high molecular weight compounds such as polynucleotides, peptides and proteins. (C) 1998 Elsevier Science B.V. All rights reserved.