NEW AND KNOWN DIKETOPIPERAZINES FROM THE CARIBBEAN SPONGE, CALYX CF PODATYPA
NEW AND KNOWN DIKETOPIPERAZINES FROM THE CARIBBEAN SPONGE, CALYX CF PODATYPA
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DOI：
10.1021/np50116a007
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发表时间：
1995-02-01
期刊：
影响因子：
--
通讯作者：
CREWS, P
中科院分区：
文献类型：
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作者：
ADAMCZESKI, M;REED, AR;CREWS, P
含有蓝藻的加勒比海海绵，花萼cf。podatypa，是从巴哈马群岛的三个地点收集的。在三个收集物中的每一个中，极性溶剂分配馏分含有六种已知化合物，包括五种二酮哌嗪[1-4，6]和苯乙酸，沿着一种新的二酮哌嗪，环-（4-甲基-R-脯氨酸-S-正缬氨酸）[5]。有趣的是，所有六种二酮哌嗪都是脯氨酸衍生的环状二肽。这是从花萼海绵中分离的这类肽衍生物的第一个例子。平行研究的海绵收集，其中的外体（蓝藻丰富）从内体（无蓝藻）分离，发现没有显着差异，其内容的二酮哌嗪。
The cyanobacteria-containing Caribbean sponge, Calyx cf. podatypa, was collected from three sites in the Bahamas. In each of the three collections, a polar solvent partition fraction contained six known compounds including five diketopiperazines [1-4, 6] and phenylacetic acid, along with a new diketopiperazine, cyclo-(4-methyl-R-proline-S-norvaline) [5]. Interestingly, all six diketopiperazines are proline-derived cyclic dipeptides. This is the first example for this class of peptide derivative to be isolated from a Calyx sponge. Parallel studies of one of the sponge collections in which the ectosome (cyanobacteria-rich) was separated from the endosome (no cyanobacteria) revealed no significant differences in their content of diketopiperazines.