Immunoreceptor tyrosine-based inhibition motif-bearing receptors regulate the immunoreceptor tyrosine-based activation motif-induced activation of immune competent cells
Immunoreceptor tyrosine-based inhibition motif-bearing receptors regulate the immunoreceptor tyrosine-based activation motif-induced activation of immune competent cells
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DOI：
10.1016/s0165-2478(99)00024-3
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发表时间：
1999-05-03
影响因子：
4.4
通讯作者：
Sármay, G
中科院分区：
文献类型：
--
作者：
Gergely, J;Pecht, I;Sármay, G
ITIM 受体是一个最近才被认识的家族，在调节 ITAM 诱导的免疫活性细胞激活中发挥着关键作用。最近阐明了各种细胞中 ITM 介导的调节机制。本综述重点关注 ITIM 承载膜蛋白，当与含有 ITAM 的受体共交联时，它会负向调节细胞的激活，阐明了 B 细胞、NK 细胞、T 细胞和肥大细胞负向调节的抑制过程，并总结了目前关于 ITIM 介导的抑制机制的观点。 (C) 1999 Elsevier Science B.V. 保留所有权利。
ITIM-bearing receptors, a family which only recently has been recognized, play a key role in the regulation of the ITAM-induced activation of immune competent cells. The mechanism of ITM-mediated regulation in various cells was recently clarified. The present review focuses on ITIM bearing membrane proteins that negatively regulate the activation of cells when co-crosslinked with ITAM containing receptors, illustrates the inhibitory processes by the negative regulation of B-, NK-, T-cells and mast cells and summarizes current views on the mechanism of ITIM-mediated inhibition. (C) 1999 Elsevier Science B.V. All rights reserved.