blaCTX-M-2 is located in an unusual class 1 integron (In35) which includes Orf513
blaCTX-M-2 is located in an unusual class 1 integron (In35) which includes Orf513
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DOI：
10.1128/aac.46.7.2303-2306.2002
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发表时间：
2002-07-01
影响因子：
4.9
通讯作者：
Centron, D
中科院分区：
文献类型：
--
作者：
Arduino, SM;Roy, PH;Centron, D
通过测序和PCR分析对质粒pMAR-12中的bla（CTX-M-2）基因进行的检查显示，bla基因和与含有bla（KLUA-1）基因的Kluyvera ascorbata染色体DNA密切相关（99%同源性）的周围DNA位于包括Orf 513的称为105的复合sul 1型整合子中。blaCTX-M-2可能是由质粒pMAR-12通过一个未表征的重组事件获得的，其中Orf 513可能参与其中。
Examination of the bla(CTX-M-2) gene in plasmid pMAR-12 by sequencing and PCR analysis revealed that the bla gene and the surrounding DNA, which is closely related (99% homology) to the Kluyvera ascorbata chromosomal DNA that contains the bla(KLUA-1) gene, are located in a complex sul1-type integron, termed 105, that includes Orf513. It is possible that blaCTX-M-2 was acquired by plasmid pMAR-12 through an uncharacterized recombinational event in which Orf513 could be involved.