THE EFFECTS OF SUGGESTION AND EMOTIONAL AROUSAL ON PULMONARY-FUNCTION IN ASTHMA - A REVIEW AND A HYPOTHESIS REGARDING VAGAL MEDIATION
THE EFFECTS OF SUGGESTION AND EMOTIONAL AROUSAL ON PULMONARY-FUNCTION IN ASTHMA - A REVIEW AND A HYPOTHESIS REGARDING VAGAL MEDIATION
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DOI：
10.1097/00006842-199203000-00006
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发表时间：
1992-03-01
影响因子：
3.3
通讯作者：
HOCHRON, S
中科院分区：
文献类型：
--
作者：
ISENBERG, SA;LEHRER, PM;HOCHRON, S
本文回顾了有关哮喘、暗示和情绪之间关系的经验文献，并提出了这些效应是通过副交感神经介导的假说。文献表明，在哮喘患者中，暗示可以产生支气管收缩和支气管扩张，而压力可以产生支气管收缩。在所有研究中，对暗示和应激均表现出支气管收缩的哮喘受试者比例平均为35%-40%，但出于方法学考虑，保守估计可能接近20%。提示支气管扩张的效果较小，并且在非哮喘患者中持续时间很短。这些反应与年龄、性别、哮喘严重程度、特应性或肺部评估方法等受试者变量之间没有明确的联系，尽管出现了一些不显著的趋势。该文献中的大多数研究使用小n，并且没有系统地检查可能影响结果的各种躯体，环境和人口统计学因素。一个假设是关于迷走神经介导的心理影响的气道，以及可能的替代机制，并建议未来的研究，以评估这些假设。
This paper reviews the empirical literature on the relation between asthma, suggestion, and emotion, and proposes the hypothesis that these effects are mediated parasympathetically. The literature indicates that, among asthmatics, suggestion can produce both bronchoconstriction and bronchodilation, and that stress can produce bronchoconstriction. The proportion of asthmatic subjects showing bronchoconstriction to both suggestion and stress averages 35%-40% across studies, but, because of methodological considerations, might be conservatively estimated as closer to 20%. The effect is smaller for suggestion of bronchodilation, and is very short-lived among nonasthmatics. No clear connection has been found between these responses and such subject variables as age, gender, asthma severity, atopy, or method of pulmonary assessment, although some nonsignificant tendencies appear. Most studies in this literature used small n's and did not systematically examine various somatic, environmental, and demographic factors that could influence results. A hypothesis is presented regarding vagal mediation of psychological effects on the airways, as well as possible alternative mechanisms, and recommendations for future research to evaluate these hypotheses.