Expressions of Nucleoside Diphosphate Kinase (nm23) in Tumor Tissues are Related with Metastasis and Length of Survival of Patients with Hepatocellular Carcinoma
Expressions of Nucleoside Diphosphate Kinase (nm23) in Tumor Tissues are Related with Metastasis and Length of Survival of Patients with Hepatocellular Carcinoma
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DOI：
10.1016/s0895-3988(10)60062-1
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发表时间：
2010-08-01
影响因子：
3.5
通讯作者：
Dong, Xiao-Ping
中科院分区：
文献类型：
--
作者：
An, Run;Meng, Jie;Dong, Xiao-Ping
目的通过分析原发性肝癌（HCC）患者的病理及临床资料，探讨nm23、增殖细胞核抗原（PCNA）的表达及细胞凋亡与HCC患者预后的关系。方法采用免疫组化法检测43例肝癌组织、39例癌旁肝组织和10例正常肝组织中nm23和PCNA的表达，TUNEL法检测细胞凋亡现象。计算细胞凋亡指数（AI）和增殖指数（PI）。结果nm23在32.6%的癌组织中呈阴性表达，而癌旁组织和正常组织均呈阳性表达。nm23阳性组AI明显高于nm23阴性组，差异有统计学意义（P
Objective To evaluate the relationship of expressions of nucleoside diphosphate kinase (nm23) and proliferating cell nuclear antigen (PCNA), as well as apoptosis, with the prognosis of HCC patients by analyzing their pathological and clinical data. Methods The expressions of nm23 and PCNA were analyzed by immunohistochemistry and the apoptotic phenomena were detected by TUNEL technique in the liver samples from 43 HCC tissues, 39 para-neoplastic tissues, and 10 normal tissues. The mean apoptosis index (AI) and proliferative index (PI) in individual sample were calculated. Results As shown by the detection, 32.6% of carcinomas had negative nm23 signal in tumor tissues, whereas all para-neoplastic and normal tissues had positive nm23. The AI in nm23 positive HCC was significantly higher than that in nm23 negative one, with statistical difference (P