Lack of Association with Rheumatoid Arthritis of Selected Polymorphisms in 4 Candidate Genes: CFH, CD209, Eotaxin-3, and MHC2TA
Lack of Association with Rheumatoid Arthritis of Selected Polymorphisms in 4 Candidate Genes: CFH, CD209, Eotaxin-3, and MHC2TA
复制标题
DOI：
10.3899/jrheum.090022
复制
发表时间：
2009-08-01
影响因子：
3.9
通讯作者：
Gonzalez, Antonio
中科院分区：
文献类型：
--
作者：
Dieguez-Gonzalez, Rebeca;Akar, Servet;Gonzalez, Antonio
Objective.研究补体因子H（CFH）、CD 209或DC-SIGN、嗜酸性粒细胞趋化因子-3（eotaxin-3）和MHC II类反式激活因子（MHC 2 TA）4个候选基因的单核苷酸多态性（SNP）与类风湿关节炎（RA）的相关性。已报道这些SNP对于RA（eotaxin-3和MHC 2 TA）或对于其他免疫介导的疾病（CFH和CD 209）是重要的。从1587例RA患者和1570例西班牙血统的对照中获得了7个选定SNP的基因型。在对性别、糜烂、类风湿因子、共有表位、抗环瓜氨酸肽抗体和R620 W PTPN 22 SNP进行分层后进行分析。RA患者和对照组之间的比较或根据疾病特征的不同患者分层之间的比较均无意义。CFH和CD 209的SNP均未显示与RA相关的证据。我们不能重复韩国人中描述的嗜酸细胞活化趋化因子-3与RA的关联，也不能重复MHC 2 T SNP的关联。（2009年7月1日首次发布; J Rheumol 2009;36：1590-5。doi：10.3899/jrheum.090022）
Objective. To investigate associations with rheumatoid arthritis (RA) of single-nucleotide polymorphisms (SNP) in 4 candidate genes, complement factor H (CFH), CD209 or DC-SIGN, eotaxin-3, and the MHC class II Transactivator (MHC2TA) genes. These SNP have been reported as important for RA (eotaxin-3 and MHC2TA) or for other immune-mediated diseases (CFH and CD209).Methods. Genotypes for the 7 selected SNP were obtained from 1587 patients with RA and 1570 controls of Spanish ancestry. Analyses were carried out after stratification for sex, erosions, rheumatoid factor, shared epitope, anti-cyclic citrullinated peptide antibodies, and the R620W PTPN22 SNP.Results. None of the comparisons between patients with RA and controls or between the different strata of patients according to disease features was significant.Conclusion. None of the SNP in CFH and CD209 showed evidence of association with RA. We (lid not replicate the association of eotaxin-3 with RA described in Koreans, or that of the MHC2T SNP. (First Release July 1 2009; J Rheumatol 2009;36:1590-5.- doi: 10.3899/jrheum.090022)