COMPOUND 84 F 1983 COMPARED WITH D-AMPHETAMINE AND PLACEBO IN REGARD TO EFFECTS ON HUMAN-PERFORMANCE
COMPOUND 84 F 1983 COMPARED WITH D-AMPHETAMINE AND PLACEBO IN REGARD TO EFFECTS ON HUMAN-PERFORMANCE
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DOI：
10.1007/bf00404009
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发表时间：
1964-01-01
期刊：
影响因子：
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通讯作者：
SHARPLEY, RP
中科院分区：
文献类型：
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作者：
HOLLIDAY, AR;MORRIS, RB;SHARPLEY, RP
本研究确定，中度疲劳的正常人摄入30 mg或60 mg 4-甲基-2-（吡咯烷基）戊苯酮盐酸盐（84/F 1983），将显著阻止安慰剂受试者在简单脑力任务中表现出的随时间推移而降低的表现。虽然服用30 mg或60 mg 84/F 1983的受试者的平均评分通常高于服用10 mg d-苯丙胺的受试者的平均评分，在这3个药物组之间没有发现统计学显著差异，除了60 mg 84/F 1983组显示出显著高于30 mg 84/F 1983组的平均性能。F 1983组于给药后1h结束。在这项研究的条件下。84/F 1983似乎是一种非常有效的精神兴奋剂，在增强人类表现方面类似于d-安非他明。这种方法的复制区分兴奋剂和安慰剂对人类的表现一个简单的心理任务的影响表明，该方法是高度可靠的。
This study establishes that ingestion of either 30 mg or 60 mg of 4-methyl-2-(pyrrolidinyl) valerophenone hydrochloride (84/F 1983) by moderately fatigued normal humans will significantly arrest the decrement in performance over time on a simple mental task shown by placebo subjects. While the mean scores of subjects ingesting either 30 mg or 60 mg of 84/F 1983 were generally higher than the mean scores of subjects ingesting 10 mg of d-amphetamine, no statistically significant difference was found between these 3 drug groups with the exception that the 60 mg 84/F 1983 group showed a significantly higher mean performance than the 30 mg 84/F 1983 group by the end of 1 hour postdrug. Under the conditions of this study. 84/F 1983 appears to be a highly effective psychostimulant which resembles d-amphetamine in its enhancing effect on human performance. The replication of this method for discriminating between the effects of stimulants and a placebo on human performance of a simple mental task shows the method to be highly reliable.