Industrial air pollution and children's respiratory health: a natural experiment in Calarasi.
Industrial air pollution and children's respiratory health: a natural experiment in Calarasi.
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DOI：
10.1080/13814780701541308
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发表时间：
2007-01-01
期刊：
影响因子：
--
通讯作者：
Manolovici, Carmen
中科院分区：
文献类型：
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作者：
Cara, Alexandra Carmen;Buntinx, Frank;Manolovici, Carmen
BACKGROUND: In 1993-1997, we described a high incidence of wheezing in children living near the iron, steel, and coke factory of Calarasi (Romania). In 1998, the factory was closed.OBJECTIVE: To investigate the influence of closing the factory on the incidence of wheezing in children living near the factory.METHODS: We used this natural experiment to compare wheezing occurrence in children below age 2 in an area near the factory and in a village 10 km from the factory (Roseti). We studied three birth cohorts: those 2 years old before the closing of the factory (group 1), those born before the closing and returning 2 after the closing (group 2), those born after the closing (group 3).RESULTS: The relative risk (95% CI) of having at least one episode of wheezing during the first life-year was 0.51 (0.30-0.85) in group 3 versus group 1, and 0.95 (0.64-1.40) for group 2 versus group 1. After adjusting for possible confounders, the incidence dropped in Calarasi (odds ratio [OR] 0.38, 95% CI 0.19-0.76), while it increased in Roseti (OR 8.36, 95% CI 1.84-38.0). Results for the 2-year incidence were similar.CONCLUSION: Industrial air pollution by the factory was the main risk factor for wheezing during the first life-years of the children of Calarasi. Closing the factory resulted in a significant decrease in wheezing incidence rates, which still remained higher than in a nearby village.
