An electron microscopic tracer study of the projections from entopeduncular nucleus to the ventrolateral nucleus of the rat
An electron microscopic tracer study of the projections from entopeduncular nucleus to the ventrolateral nucleus of the rat
复制标题
大鼠内脚核到腹外侧核投射的电镜示踪研究
DOI：
10.1016/0304-3940(96)12713-0
复制
发表时间：
1996
影响因子：
2.5
通讯作者：
M. Horne
中科院分区：
文献类型：
--
作者：
D. Finkelstein;A. Reeves;M. Horne
髓核内核（EP）被认为是基底神经节（BG）的主要流出核。将顺行示踪剂葡聚糖生物素注入EP，观察其与丘脑的联系。同侧丘脑腹前-腹外侧核（VAL）和腹内侧核（VM）、外侧束核和中心-束旁复合体均可见EP末梢。电镜显示VAL/VM末端有密集标记的小突触，突触后密度突出，有圆形囊泡。在树突和树突棘上观察到突触，但在其他突触或胞体上没有观察到突触。未标记带有多形性囊泡的对称突触。脑电与丘脑之间的突触接触为Gray 1型。这些发现对当前的BG病理生理学理论具有启示意义。
The entopeduncular (EP) nucleus is considered to be the major outflow nucleus of the basal ganglia (BG). The anterograde tracer dextran biotin was injected into EP to investigate its connections with the thalamus. Terminals from EP were found in the ipsilateral ventroanterior-ventrolateral (VAL) and ventromedial thalamic nuclei (VM), lateral habenular and centromedian-parafascicular complex. Electron microscopy of the terminals in VAL/VM revealed densely labelled small synapses that had prominent post-synaptic densities and round vesicles. Synapses were observed onto dendrites and dendritic spines but not onto other synapses or somas. No symmetrical synapses with pleomorphic vesicles were labelled. It is concluded that the synaptic contacts between EP and thalamus are Gray type 1. These findings have implications regarding current theories of BG pathophysiology.
亨廷顿病中强直和舞蹈症的神经化学底物。
DOI：
10.1093/brain/116.5.1201
发表时间：
1993
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Storey,E;Beal,MF
通讯作者：
Beal,MF