Carbon nanotube-coupled cell adhesion peptides are non-immunogenic: a promising step toward new biomedical devices
Carbon nanotube-coupled cell adhesion peptides are non-immunogenic: a promising step toward new biomedical devices
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DOI：
10.1002/psc.1290
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发表时间：
2011-02-01
影响因子：
2.1
通讯作者：
Bianco, Alberto
中科院分区：
文献类型：
--
作者：
Gaillard, Claire;Duval, Monique;Bianco, Alberto
通过细胞黏附肽功能化的碳纳米管可以被认为是开发先进的药物传递系统或设计新一代自组装神经桥的新的、有前途的候选者。在活体中整合这些类型的结合物的一个重要步骤是评估它们对免疫系统的影响。在这个方向上，整合素衍生的多肽已经共价连接到碳纳米管上。在给药后，多肽-碳纳米管不会引发抗多肽抗体的产生。多肽-碳纳米管免疫中立性的证明加强了它们作为体内神经元再生底物的潜在用途。版权所有(C)2010欧洲多肽协会和John Wiley&Sons，Ltd.
Carbon nanotubes functionalized with cell adhesion peptides can be considered as novel, promising candidates for the development of advanced drug delivery systems or for designing new generation of self-assembling nerve 'bridges'. An important step toward the integration of these types of conjugates in living bodies is the assessment of their impact on the immune system. In this direction, an integrin-derived peptide has been covalently conjugated to carbon nanotubes. Following intraperitoneal administration, peptide-carbon nanotubes do not trigger an anti-peptide antibody production. Demonstration of the immune neutrality of peptide-carbon nanotubes reinforces their potential use as substrates for neuronal regeneration in vivo. Copyright (C) 2010 European Peptide Society and John Wiley & Sons, Ltd.